Introdução: O câncer de mama aparece como o segundo tipo de neoplasia maligna causando a morte das mulheres no mundo. A heterogeneidade tumoral, e as vias pelas quais as células neoplásicas interagem representam grande relevância no desenvolvimento do câncer de mama. No tumor são encontradas alte...
Neoplasias de la Mama/genética,
Metilación de ADN/genética,
Neoplasias de la Mama/diagnóstico,
ADN Tumoral Circulante/análisis,
Genes Supresores de Tumor,
Carcinoma de Mama in situ/patología,
Carcinoma Lobular,
Inmunohistoquímica,
Progesterona,
Pronóstico,
Estrógenos
Abstract Genetic and epigenetic changes have been associated with periodontitis in various genes; however, little is known about genes involved in epigenetic mechanisms and in oxidative stress. Objective: This study aims to investigate the association of polymorphisms C677T in MTHFR (rs1801133) and W...
Estudios de Casos y Controles,
Catalasa/genética,
ADN (Citosina-5-)-Metiltransferasas/genética,
Metilación de ADN/genética,
Estudios de Asociación Genética,
Genotipo,
Metilenotetrahidrofolato Reductasa (NADPH2)/genética,
MicroARNs/genética,
Periodontitis/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Polimorfismo de Longitud del Fragmento de Restricción,
Superóxido Dismutasa-1/genética
Abstract: Objective: To perform a systematic review of the main epigenetic aberrations involved in non-small cell lung carcinomas' (NSCLC) diagnosis, progression, and therapeutics. Materials and methods: We performed a systematic review of the scientific literature on lung cancer epigenetics, focusin...
ABSTRACT BACKGROUND: There is evidence that genetic predisposition and epigenetic alteration (e.g. DNA methylation) play major roles in lung cancer. In our genetic epidemiological studies, rs1970764 in oncogene PPP1R13L was most consistently associated with lung cancer risk. Here, we explored the role ...
BACKGROUND: The purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of nasopharyngeal carcinoma cells. METHODS: The levels of methylation and expression of the DACT1 gene in nasopharyngeal carcinoma tissues and CNE2 cells wer...
Proteínas Adaptadoras Transductoras de Señales/genética,
Metilación de ADN/genética,
Carcinoma Nasofaríngeo/secundario,
Neoplasias Nasofaríngeas/patología,
Proteínas Nucleares/genética,
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Metilación de ADN/fisiología,
Carcinoma Nasofaríngeo/genética,
Neoplasias Nasofaríngeas/genética,
Proteínas de Neoplasias/metabolismo,
Proteínas Nucleares/metabolismo,
Invasividad Neoplásica,
Regiones Promotoras Genéticas
O cuidado materno negligente, a falta de afeto e a dificuldade de interagir socialmente
estão relacionadas com o desequilíbrio neurofisiológico da ocitocina, neurormônio
com papel importante de modulação dos comportamentos sociais. Em seres humanos
existem ligações conhecidas entre o estresse ...
O câncer de mama representa a primeira causa de morte por câncer no mundo para mulheres. Neste contexto, a detecção precoce do câncer de mama aumenta consideravelmente as chances de cura. Entretanto a caracterização das lesões iniciais e impalpáveis tem se tornado um desafio. Histologicamente es...
Biomarcadores de Tumor/química,
Neoplasias de la Mama/prevención & control,
Mama/lesiones,
Metilación de ADN/genética,
Detección Precoz del Cáncer/métodos,
Genes Supresores de Tumor,
Deficiencia de Vitamina D/sangre,
Células Neoplásicas Circulantes/química,
Saliva,
ADN de Neoplasias/sangre,
ADN Tumoral Circulante/sangre
Luna, R C P;
de Oliveira, Y;
Lisboa, J V C;
Chaves, T R;
de Araújo, T A M;
de Sousa, E E;
Miranda Neto, M;
Pirola, L;
Braga, V A;
de Brito Alves, J L.
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart fail...
Metilación de ADN/genética,
Regulación hacia Abajo/genética,
Epigénesis Genética/genética,
Código de Histonas/genética,
Hipertensión Pulmonar/genética,
Hipertensión Pulmonar/fisiopatología,
Hipertensión Pulmonar/terapia,
Terapia Molecular Dirigida,
Arteria Pulmonar/patología,
ARN no Traducido/genética,
Ubiquitinación/genética,
Regulación hacia Arriba/genética
Abstract: Background: epigenomes can be influenced by environmental factors leading to the development of diseases. Objective: To investigate the influence of sun exposure on global DNA methylation and hydroxymethylation status and at specific sites of the miR-9-1, miR-9-3 and MTHFR genes in skin sampl...
Factores de Edad,
Metilación de ADN/genética,
Ensayo de Inmunoadsorción Enzimática,
Epigenómica,
Metilenotetrahidrofolato Reductasa (NADPH2)/genética,
MicroARNs/genética,
Reacción en Cadena de la Polimerasa,
Exposición a la Radiación,
Valores de Referencia,
Factores Sexuales,
Piel/química,
Piel/efectos de la radiación,
Enfermedades de la Piel/etiología,
Luz Solar/efectos adversos
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a...
