BACKGROUND: Xenotransplantation has been primarily performed using fresh donor tissue to study testicular development for about 20 years, and whether the cultured tissue would be a suitable donor is unclear. In this study, we combined testicular culture and xenotransplantation into an integrative model a...
This study was devoted to the Resonant Recognition Model (RRM) analysis of SARS-CoV-2 proteins and their possible interaction with other human proteins, specifically, SARS CoV replicases and methyl transferases, were tested, via RRM analysis, for possible interactions with host CD4 T receptor proteins an...
Abstract INTRODUCTION: This study aimed to determine the role of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S rRNA methylase (ArmA) in Acinetobacter baumannii clinical isolates. METHODS: We collected 100 clinical isolates of A. baumannii and identified and confirmed them using micro...
SUMMARY: The Mettl3/Mettl14 methyltransferase complex installs the most ubiquitous internal mRNA modification- N6-methyladenosine (m6A). The vertebrate retina development is a multi-step process that requires fine-tuning of multiple cellular events, but very little is known about the potential function o...
Samer, Sadia;
Arif, Muhammad Shoaib;
Giron, Leila Bertoni;
Zukurov, Jean Paulo Lopes;
Hunter, James;
Santillo, Bruna Teresa;
Namiyama, Gislene;
Galinskas, Juliana;
Komninakis, Shirley Vasconcelos;
Oshiro, Telma Miyuki;
Sucupira, Maria Cecilia;
Janini, Luiz Mario;
Diaz, Ricardo Sobhie.
ABSTRACT Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BI...
Azepinas/farmacología,
Infecciones por VIH/virología,
VIH-1/efectos de los fármacos,
Metiltransferasas/antagonistas & inhibidores,
Niacinamida/farmacología,
Quinazolinas/farmacología,
Activación Viral/efectos de los fármacos,
Linfocitos T CD4-Positivos,
Regulación Viral de la Expresión Génica,
Leucocitos Mononucleares/virología,
Piperazinas/farmacología,
Carga Viral/efectos de los fármacos,
Tropismo Viral/efectos de los fármacos,
Latencia del Virus
La azatioprina es una tiopurina que presenta rango terapéutico estrecho y marcada toxicidad hematológica y hepática. La tiopurina S-metiltransferasa es una enzima que metaboliza ese grupo de drogas. Mutaciones en el gen que codifica dicha enzima aumentan el riesgo de presentar eventos adversos, por lo...
RESUMEN El objetivo del estudio fue evaluar la relación de los polimorfismos rs11191439 y rs3740393 del gen Arsénico 3 Metiltransferasa (As3MT) con los perfiles de excreción urinaria de arsénico, en una población del norte de México. Se realizó un estudio transversal con 102 participantes de 14 a ...
ABSTRACT Saccharum spontaneum has been used for the development of energy cane a crop aimed to be used for the production of second-generation ethanol, or lignocellulosic ethanol. Lignin is a main challenge in the conversion of cell wall sugars into ethanol. In our studies to isolate the genes the lignin...
Os aminoglicosídeos (AGs) são antimicrobianos utilizados no tratamento de infecções graves causadas por bacilos Gram-negativos (BGNs), e são umas das poucas opções terapêuticas contra microrganismos multirresistentes no ambiente hospitalar. Contudo, há diversos relatos da produção de enzimas.....
