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Metronidazole thermogel improves retention and decreases permeation through the skin

Melo, Elayne Karine Souto de; Araujo, Thalita Pedon de; Silva, José Wellithom Viturino da; Chagas, Stephanye Carolyne Christino; Bedor, Danilo César Galindo; Santana, Davi Pereira de; Leal, Leila Bastos.
Braz. J. Pharm. Sci. (Online); 53 (2), 2017
ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly...
Metronidazol/análisis, Piel/diagnóstico por imagen, Poloxámero/farmacología, Rosácea/prevención & control, Dermatología/clasificación, Termogénesis, Anomalías Cutáneas/complicaciones
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Efecto del metronidazol suplementado con hidroquinona en la adherencia de Lactobacillus acidophilus en células vaginales ovinas
Effect of metronidazole supplemented with hydroquinone on the adhesion of Lactobacillus acidophilus in ovine vaginal cells

Coletti Zabala, Tamara L; Zerbatto, María E; Perotti, Elda B. R; Smacchia, Ana M; Ombrella, Adriana; Pidello, Alejandro R.
Rev. argent. microbiol; 48 (4), 2016
This work demonstrates that the addition of metronidazole together with a ubiquitous quinone compound reduces adherence of Lactobacillus acidophilus to ovine vaginal cells. Spectrophotometric and voltammetric studies have shown that neoformed compounds were observed in these systems; there were also chan...
Adhesión Bacteriana/efectos de los fármacos, Metronidazol/farmacología, Metronidazol/análisis, Enfermedades Vaginales/veterinaria, Enfermedades de las Ovejas/prevención & control, Oxidación-Reducción/efectos de los fármacos, Espectrofotometría/métodos, Ovinos/microbiología
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