Inflammatory myopathies belong to a heterogeneous group of autoimmune diseases, which are mainly characterized by muscle weakness, elevated muscle enzymes, myopathic changes on electromyography, and muscle biopsy abnormalities. They may also have extraocular manifestations as well as involvement of the l...
Miositis/diagnóstico,
Enfermedades Autoinmunes/diagnóstico,
Miositis/genética,
Enfermedades Autoinmunes/genética,
MicroARNs,
Músculo Esquelético,
ARN no Traducido/genética,
Prevalencia,
Signos y Síntomas,
Distribución por Edad y Sexo,
Comorbilidad,
Anticuerpos
Os microRNA circulantes são pequenos RNA não codificantes que se apresentam como potenciais biomarcadores de doenças crônicas não transmissíveis (DCNT) e uma ferramenta para o manejo terapêutico. Diante do exposto, o estudo em tela teve como objetivo avaliar o perfil de expressão de microRNA plas...
A toxoplasmose é uma zoonose cosmopolita e quando a infecção ocorre durante a gravidez (toxoplasmose gestacional) o parasita pode atravessar a placenta, causando a forma congênita, e causar danos graves. Investigar como os microRNAs regulam a infecção pode oferecer informações valiosas sobre sua ...
SUMMARY: Keloid scar is a unique benign fibroproliferative tumor of the human skin. Previously, it was reported that early growth response 1 (EGR1), a transcription factor, promotes keloid fibrosis; however, the mechanism by which EGR1 modulates keloid formation was not elaborated. In this research, the ...
Fibroblastos,
Queloide/patología,
Transfección,
Queloide/genética,
MicroARNs/fisiología,
Proteína 1 de la Respuesta de Crecimiento Precoz,
Apoptosis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Proliferación Celular,
Movimiento Celular,
Regulación hacia Abajo,
d0347410,
Análisis de Secuencia de ARN,
Cicatrización de Heridas
SUMMARY: We investigated the expression and clinical significance of miR-15b-5p in clear cell renal cell carcinoma (RCC) through bioinformatics analysis and experimental verification. The differentially expressed miRNAs were screened in the GEO database. Venn diagram showed that there were 5 up-regulated...
Neoplasias Renales/patología,
Neoplasias Renales/genética,
Carcinoma de Células Renales/patología,
Carcinoma de Células Renales/genética,
MicroARNs,
Metástasis de la Neoplasia,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Invasividad Neoplásica,
Biología Computacional,
Análisis de Supervivencia,
Movimiento Celular
Introduction: Hansen’s disease, or leprosy is caused by Mycobacterium leprae (M. leprae), is a major public health problem in developing countries, and affecting the skin and peripheral nerves. However, M. leprae can also affect bone tissue, mucous membranes, liver, eyes, and testicles, producing a var...
Lepra,
MicroARNs,
Biomarcadores,
Mycobacterium leprae,
Nervios Periféricos,
Piel,
Huesos,
Membrana Mucosa,
Hígado,
Ojo,
Testículo
MicroRNAs (miRNAs) are small non-coding RNA molecules that play critical roles in post-transcriptional gene regulation. They function by binding to target messenger RNA (mRNA) molecules, leading to their degradation or inhibiting their translation i...
Abstract MicroRNAs (miRNAs) are essential nonprotein-coding genes. In a range of organisms, miRNAs has been reported to play an essential role in regulating gene expressions at post-transcriptional level. They participate in most of the stress responsive processes in plants. Drought is an ultimate abioti...
Albadawy, Reda;
Hasanin, Amany Helmy;
Agwa, Sara H. A;
Hamady, Shaimaa;
Mohamed, Reham Hussein;
Gomaa, Eman;
Othman, Mohamed;
Yahia, Yahia A;
Ghani, Amani Mohamed Abdel;
Matboli, Marwa.
BACKGROUND: Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate the potential effect of benzyl propylene glycoside on NAFP management via targeting ...
