BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and ischemic tissue ...
SUMMARY: This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in the development of psoriasis vulgaris. RT-PCR was used to compare the levels of miR-34a in the skin lesions of 20 patients with psoriasis vulgaris and 20 normal skin tissues. Immunohistochemistry was used to detect the...
Psoriasis/genética,
Psoriasis/metabolismo,
MicroARNs/genética,
MicroARNs/metabolismo,
Receptor Notch1/genética,
Receptor Notch1/metabolismo,
Factores de Transcripción Forkhead/genética,
Factores de Transcripción Forkhead/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Inmunohistoquímica,
Transfección,
Western Blotting
BACKGROUND: Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells (CSCs) and cancer cells plays an important role in metastatic dissemination. Whethe...
ABSTRACT Despite advances in understanding of carcinogenesis and of treatment of acute myeloid leukemia, this neoplasm still has a lethality of at least 30%. The search for biomarkers that can predict the response to treatment in the early stages of the disease is still necessary. In recent years, a new ...
De-Russi, Brenno Marco;
Porsani, Lucas Barbosa;
Cirino, Mucio Luiz de Assis;
Silva, Jairo Pinheiro da;
Turra, Letícia Passi;
Novais, Paulo Cezar;
Lizarte-Neto, Fermino Sanches;
Fazan, Valéria de Paula Sassoli;
Thomazini, José Antônio;
Colli, Benedicto Oscar;
Tirapelli, Daniela Pretti da Cunha;
Tirapelli, Luis Fernando;
Carvalho, Camila Albuquerque Melo de.
SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of m...
La diabetes Tipo 1 (DT1) es una compleja enfermedad autoinmune con una etiología aún desconocida. La vitamina D ha sido ampliamente estudiada debido a su potencial terapéutico en los potenciales nuevos casos de DT1. Por otra parte, los microARNs (miRs) han sido propuestos como posibles biomarcadores e...
Apoptosis,
Diabetes Mellitus Tipo 1/metabolismo,
Biomarcadores,
Vitamina D/administración & dosificación,
MicroARNs/metabolismo,
MicroARNs/genética,
Vitamina D/metabolismo,
Proteínas Proto-Oncogénicas c-bcl-2/metabolismo,
Proteínas Proto-Oncogénicas c-bcl-2/genética,
Chaperonas Moleculares/metabolismo,
Proteínas Co-Represoras/metabolismo,
Factor de Transcripción STAT3/metabolismo,
Chaperonas Moleculares/genética,
Proteínas Co-Represoras/genética,
Factor de Transcripción STAT3/genética,
Glucosa/administración & dosificación,
MicroARNs/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-bcl-2/efectos de los fármacos,
Chaperonas Moleculares/efectos de los fármacos,
Proteínas Co-Represoras/efectos de los fármacos,
Factor de Transcripción STAT3/efectos de los fármacos
Patients with osteosarcoma (OS) usually have poor overall survival because of frequent metastasis. Long non-coding RNAs (lncRNAs) have been reported to be associated with tumorigenesis and metastasis. In this study, we investigated the expression and roles of lncRNA human histocompatibility leukocyte ant...
Neoplasias Óseas/genética,
Neoplasias Óseas/patología,
Línea Celular Tumoral,
Movimiento Celular,
Proliferación Celular,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
MicroARNs/metabolismo,
Invasividad Neoplásica,
Osteosarcoma/genética,
Osteosarcoma/patología,
ARN Largo no Codificante/genética,
Receptor EphA7/metabolismo
Sarraipo, Vagner Schiavoni;
Lizarte Neto, Fermino Sanches;
Carvalho, Camila Albuquerque Mello de;
Silva, Jairo Pinheiro da;
Durand, Marina Toledo;
Schimming, Bruno Cezar;
Martinez, Marcelo;
Galli, Maria de Fátima Tazima Sorita;
Buono, Fabianna de Oliveira;
Tiezzi, Maria Fernanda Barbirato da Mata;
Novais, Paulo Cezar;
Gula, Isabella Stracieri;
Thomazini, José Antônio;
Fazan, Valeria Paula Sassoli;
Rodrigues, Andressa Romualdo;
Tirapelli, Daniela Pretti da Cunha;
Cirino, Mucio Luiz de Assis;
Molina, Carlos Augusto Fernandes;
Junior, Silvio Tucci;
Tirapelli, Luis Fernando.
SUMMARY: Previous studies from our group described the consequences of using ethanol on penile erection. Nevertheless, the molecular mechanisms surrounding microRNAs, apoptosis process and their relationship with erectile dysfunction associated with alcohol consumption are still poorly understood. The ob...
Alcoholismo/metabolismo,
Disfunción Eréctil/metabolismo,
Apoptosis,
MicroARNs/metabolismo,
Factor Inductor de la Apoptosis/metabolismo,
Pene/química,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ratas Wistar,
MicroARNs/análisis,
Factor Inductor de la Apoptosis/análisis,
Alcoholismo/fisiopatología,
Disfunción Eréctil/fisiopatología,
Pene/fisiopatología,
Reacción en Cadena en Tiempo Real de la Polimerasa,
MicroARNs/genética,
Factor Inductor de la Apoptosis/genética
Abrahão, Dayana Pousa Siqueira;
Lizarte Neto, Fermino Sanches;
Rodrigues, Andressa Romualdo;
Cirino, Múcio Luiz de Assis;
Silva, Jairo Pinheiro da;
Sarraipo, Vagner Schiavoni;
Carvalho, Camila Albuquerque Melo de;
Tazima, Maria de Fátima Galli Sorita;
Carlotti-Jr, Carlos Gilberto;
Colli, Benedicto Oscar;
Tirapelli, Luís Fernando;
Tirapelli, Daniela Pretti da Cunha.
The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 proteins in rats subm...
Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. ...
Apoptosis/genética,
Apoptosis/fisiología,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proliferación Celular/fisiología,
Regulación Neoplásica de la Expresión Génica,
MicroARNs/genética,
MicroARNs/metabolismo,
ARN Largo no Codificante/genética,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Regulación hacia Arriba,
Neoplasias del Cuello Uterino/metabolismo,
Neoplasias del Cuello Uterino/patología,
Quinasas Asociadas a rho/genética,
Quinasas Asociadas a rho/metabolismo
