Exosomes are 30-120nm bio particles transferred from donor to recipient cells leading to modification in their regulatory mechanisms depending upon the coded message in the form of loaded biomolecule. Cancer cells derived exosomes the true representatives of the parent cells have been found to modify the...
Abstract Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved fro...
ABSTRACT Despite advances in understanding of carcinogenesis and of treatment of acute myeloid leukemia, this neoplasm still has a lethality of at least 30%. The search for biomarkers that can predict the response to treatment in the early stages of the disease is still necessary. In recent years, a new ...
A pesar de que los procesos epigenéticos son estudiados ampliamente de forma general, no se habían relacionado, hasta ahora, a las alteraciones genéticas más tradicionales asociadas en la etiopatogenia del cáncer oral. La visión de carcinogénesis tradicional y la de la epigenética convergen en la...
Tumor heterogeneity is the concept that different tumor cells provide distinct
biomorphological lesions, gene expressions, proliferation, microenvironment and
graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently
discussed about the interesting interaction of chronic infla...
Neoplasias Encefálicas/genética,
Heterogeneidad Genética,
Evolución Clonal/genética,
Células Madre Neoplásicas/citología,
Glioma/genética,
Nicho de Células Madre/genética,
Microambiente Tumoral,
Microambiente Celular/genética,
Proteínas Tirosina Quinasas Receptoras/genética,
Resistencia a Antineoplásicos/genética,
Perfilación de la Expresión Génica,
RNA-Seq
Peres, Karina Colombera;
Teodoro, Larissa;
Amaral, Laís Helena Pereira;
Teixeira, Elisângela Souza;
Barreto, Icléia Siqueira;
Freitas, Leandro Luiz Lopes de;
Maximo, Valdemar;
Assumpção, Lígia V. Montalli;
Bufalo, Natassia Elena;
Ward, Laura Sterian.
ABSTRACT Objective: Abnormalities involving the TGFB1 gene and its receptors are common in several types of cancer and often related to tumor progression. We investigated the role of single nucleotide polymorphisms (SNP) in the susceptibility to cancer, their impact on its features, as well as the role ...
Abstract Objective Type-I collagen (Col-I) is one of the main macromolecules of the extracellular matrix, and it is involved in the desmoplastic stromal reaction, an indicator of worse prognosis in cases of colorectal cancer (CRC). The purpose of the present study was to investigate Col-I expression in...
O câncer gástrico (CG) tem grande importância clínica devido a suas altas taxas de incidência e mortalidade estando entre os cinco tipos de câncer mais frequentes no mundo. O CG encontra-se associado ao diagnóstico tardio, que, somado a agressividade da doença, resulta em sobrevida mediana curta....
El cáncer gástrico (CG) es la neoplasia del tubo digestivo más prevalente en el mundo, asociada a factores genéticos del hospedero y externos, como infección por Helicobacter pylori. La patogénesis incluye inflamación crónica mediada por citocinas del microambiente tumoral, detectables sistémica...
Células TH1,
Neoplasias Gástricas/complicaciones,
Plasma/química,
Tracto Gastrointestinal/patología,
Adenocarcinoma/complicaciones,
Citocinas/análisis,
Infecciones por Helicobacter/complicaciones,
Inmunoglobulina G/análisis,
Interleucina-1/análisis,
Interleucina-10/análisis,
Interleucina-6/análisis,
Microambiente Tumoral,
Células Th2,
Células Th17,
Neoplasias/complicaciones,
Biomarcadores de Tumor/análisis
The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or miR-21 mimics transfected-HEF in the tran...
Apoptosis,
Proteínas Reguladoras de la Apoptosis/metabolismo,
Carcinoma,
Línea Celular Tumoral,
Proliferación Celular,
Cisplatino/farmacología,
Neoplasias Esofágicas/tratamiento farmacológico,
Neoplasias Esofágicas/genética,
Fibroblastos/metabolismo,
MicroARNs/genética,
Proteínas de Unión al ARN,
Microambiente Tumoral
