Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 2

The influence of sepsis on antimicrobials tissue penetration: The use of microdialysis technique to access free drug distribution

Santos-Borges, Karolina Torres; Henz, Pricilla; Araújo, Bibiana Verlindo de.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Sepsis is described as a life-threatening organ dysfunction caused by a host's response to infection, leading to an unbalance in body homeostasis. It is one of the leading causes of death in developed countries. Considering that in critically ill patients, such as those with sepsis, plasma conce...
Sepsis/patología, Microdiálisis/métodos, Preparaciones Farmacéuticas/provisión & distribución, Antiinfecciosos/farmacología, Farmacocinética, Acciones Farmacológicas
Fulltext

Extracellular adenosine 5'-triphosphate concentrations changes in rat spinal cord associated with the activation of urinary bladder afferents. A microdialysis study.

Rocha, Jeová Nina.
Einstein (Säo Paulo); 14 (4), 2016
ABSTRACT Objective To determine adenosine 5’-triphosphate levels in the interstice of spinal cord L6-S1 segment, under basal conditions or during mechanical and chemical activation of urinary bladder afferents. Methods A microdialysis probe was transversally implanted in the dorsal half of spin...
Adenosina Trifosfato/análisis, Microdiálisis/métodos, Neuronas Aferentes/fisiología, Médula Espinal/química, Vejiga Urinaria/inervación, Aferentes Viscerales, Adenosina Trifosfato/farmacología, Mediciones Luminiscentes, Neuronas Aferentes/efectos de los fármacos, Neuronas Aferentes/metabolismo, Ratas Sprague-Dawley, Médula Espinal/efectos de los fármacos, Vejiga Urinaria/efectos de los fármacos
Fulltext