LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Características clínicas y epidemiológicas de las neoplasias mieloproliferativas Philadelphia negativas en el sistema público de salud de Chile

Valladares, Ximena; Benavente, Rafael; Rojas, Christine; Peña, Camila; Valenzuela, Rodrigo; Monardes, Virginia; López, Hernán; Abarca, Marcelo; León, Pilar; Osorio, Rocío; Pérez, Erika; Soto, Pablo; Rocca, Gabriel La; Cardemil, Daniela; Torres, Vivianne; Intriago, Marvila; Cabrera, María Elena; Undurraga, María Soledad.

Rev. méd. Chile; 149 (11), 2021

BACKGROUND: Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF). ...

Chile/epidemiología, Janus Quinasa 2/genética, Mutación, Trastornos Mieloproliferativos/diagnóstico, Trastornos Mieloproliferativos/epidemiología, Trastornos Mieloproliferativos/genética, Policitemia Vera/diagnóstico, Policitemia Vera/epidemiología, Policitemia Vera/genética, Mielofibrosis Primaria/diagnóstico, Mielofibrosis Primaria/epidemiología, Mielofibrosis Primaria/genética, Trombocitemia Esencial/diagnóstico, Trombocitemia Esencial/genética

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CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis

Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycop...