LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis

Yang, Ying; Yan, Wei; Liu, Zhuogang; Wei, Minjie.

Braz. j. med. biol. res; 52 (5), 2019

Multiple myeloma (MM) is a malignant neoplasm of plasma, and exhibits several harmful effects including osteolytic injuries, hypercalcemia, and immune dysfunction. Many patients with MM succumb to the underlying malignancy. An S-phase kinase-related protein 2 (Skp2) inhibitor, designated SKPin C1, has be...

Apoptosis, Ciclo Celular, Proliferación Celular/efectos de los fármacos, Proliferación Celular/fisiología, Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo, Inhibidor p27 de las Quinasas Dependientes de la Ciclina/farmacología, Mieloma Múltiple/metabolismo, Mieloma Múltiple/fisiopatología, Proteínas Quinasas Asociadas a Fase-S/antagonistas & inhibidores, Proteínas Quinasas Asociadas a Fase-S/metabolismo, Proteínas Ubiquitinadas/metabolismo, Ubiquitinación/fisiología

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Relevance of prognostic factors in the decision-making of stem cell transplantation in Myelodysplastic Syndromes

Duarte, Fernando Barroso; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza Cavalcante; Kaufman, Jacques; Vasconcelos, João Paulo de; Lemes, Romélia Pinheiro Gonçalves; Rocha, Francisco Dário; Coutinho, Diego Ferreira; Zalcberg, Ilana; Vasconcelos, Paulo Roberto Leitão de.

Rev. Assoc. Med. Bras. (1992, Impr.); 62 (supl.1), 2016

ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to ...

Análisis de Varianza, Biomarcadores, Estudios de Casos y Controles, Daño del ADN/fisiología, Trasplante de Células Madre Hematopoyéticas/métodos, Linfoma/genética, Linfoma/mortalidad, Linfoma/cirugía, Malondialdehído/análisis, Mieloma Múltiple/genética, Mieloma Múltiple/metabolismo, Mieloma Múltiple/cirugía, Estrés Oxidativo/fisiología, Valores de Referencia, Factores de Tiempo, Trasplante Autólogo/métodos, Resultado del Tratamiento

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Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation

Santos, Thayna Nogueira dos; Duarte, Fernando Barroso; Maia Filho, Pedro Aurio; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza Cavalcante; Almeida Filho, Tarcísio Paulo de; Cavalcanti, Bruno Coelho; Vasconcelos, Paulo Roberto Leitão de; Dutra, Luana Leticia; Lopes, Germison Silva; Costa, Franciclea Oliveira; Leitão, João Paulo Vasconcelos; KauFman, Jacques; AraúJo, Beatriz Stella Pitombeira; Barroso, Karine Sampaio Nunes; Lemes, Romélia Pinheiro Gonçalves.

Rev. Assoc. Med. Bras. (1992, Impr.); 62 (supl.1), 2016

ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) ...

Análisis de Varianza, Biomarcadores, Estudios de Casos y Controles, Daño del ADN/fisiología, Trasplante de Células Madre Hematopoyéticas/métodos, Linfoma/genética, Linfoma/metabolismo, Linfoma/cirugía, Malondialdehído/análisis, Mieloma Múltiple/genética, Mieloma Múltiple/metabolismo, Mieloma Múltiple/cirugía, Estrés Oxidativo/fisiología, Valores de Referencia, Factores de Tiempo, Trasplante Autólogo, Resultado del Tratamiento

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