Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae
Rev. Soc. Bras. Med. Trop; 49 (2), 2016
Abstract: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years. Here, we investigated the relationship between tigecycline resistance and the expression of ef...
Acinetobacter baumannii/efectos de los fármacos, Acinetobacter baumannii/genética, Antibacterianos/farmacología, Farmacorresistencia Bacteriana/genética, Regulación Bacteriana de la Expresión Génica, Klebsiella pneumoniae/efectos de los fármacos, Pruebas de Sensibilidad Microbiana, Minociclina/análogos & derivados, Minociclina/farmacocinética, Tipificación de Secuencias Multilocus, Reacción en Cadena en Tiempo Real de la Polimerasa, Tigeciclina