CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cells
Electron. j. biotechnol; 40 (), 2019
Background: Myostatin (MSTN) negatively regulates muscle mass and is a potent regulator of energy metabolism. However, MSTN knockout have affect mitochondrial function. This research assessed the mitochondrial energy metabolism of Mstn−/+ KO cells, and wondered whether the mitochondria biogenesis are a...
Mitocondrias/genética, Mitocondrias/metabolismo, Edición Génica, Sistemas CRISPR-Cas, Miostatina/genética, Diferenciación Celular, Mioblastos/metabolismo, Mioblastos/citología, MicroARNs, Proliferación Celular, Immunoblotting, Citometría de Flujo, Biogénesis de Organelos, Músculo Esquelético/citología, Músculo Esquelético/metabolismo