Abstract An acute respiratory syndrome caused by SARS-CoV2 was declared a pandemic by the World Health Organization. Current data in the world and in Brazil show that approximately 40% of patients who died have some type of cardiac comorbidity. There are also robust reports showing an increase in IL-6 / ...
SARS-CoV-2/patogenicidad,
Miocardio/inmunologÃa,
SÃndrome Respiratorio Agudo Grave,
Coronavirus/patogenicidad,
Arritmias CardÃacas/complicaciones,
COVID-19/complicaciones,
Citocinas,
Disfunción Ventricular Izquierda/fisiopatologÃa,
Linfopenia/complicaciones,
Insuficiencia CardÃaca/complicaciones,
Miocitos CardÃacos/patologÃa,
Arritmias CardÃacas/fisiopatologÃa,
Citocinas/inmunologÃa,
Insuficiencia CardÃaca/etiologÃa
Silva, Vitor Loureiro da;
Souza, Sérgio Luiz Borges de;
Mota, Gustavo Augusto Ferreira;
Campos, Dijon H. S;
Melo, Alexandre Barroso;
Vileigas, Danielle Fernandes;
SantAna, Paula Grippa;
Coelho, Priscila Murucci;
Bazan, Silméia Garcia Zanati;
Leopoldo, André Soares;
Cicogna, Antônio Carlos.
Resumo Fundamento O remodelamento cardÃaco patológico se caracteriza por disfunção diastólica e sistólica, levando à insuficiência cardÃaca. Neste contexto, o cenário disfuncional do trânsito de cálcio miocárdico (Ca2+) tem sido pouco estudado. Um modelo experimental de estenose aórtica t...
Troncoso, Mayarling Francisca;
Pavez, Mario;
Wilson, Carlos;
Lagos, Daniel;
Duran, Javier;
Ramos, Sebastián;
Barrientos, Genaro;
Silva, Patricio;
Llanos, Paola;
Basualto-Alarcón, Carla;
Westenbrink, B. Daan;
Lavandero, Sergio;
Estrada, Manuel.
BACKGROUND: Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kinase (AMPK)â€...
Reperfusion strategies in acute myocardial infarction (AMI) can cause a series of additional clinical damage, defined as myocardial ischemia/reperfusion (I/R) injury, and thus there is a need for effective therapeutic methods to attenuate I/R injury. miR-26a-5p has been proven to be an essential regulato...
Western Blotting,
Modelos Animales de Enfermedad,
CitometrÃa de Flujo,
Ratones Endogámicos C57BL,
MicroARNs/metabolismo,
Isquemia Miocárdica/metabolismo,
Daño por Reperfusión Miocárdica/metabolismo,
Miocitos CardÃacos/patologÃa,
Fosfohidrolasa PTEN/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
ProteÃnas Proto-Oncogénicas c-akt/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed ...
Hipoxia de la Célula/efectos de los fármacos,
LÃnea Celular,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Emodina/uso terapéutico,
Hipoxia/complicaciones,
MicroARNs,
Miocitos CardÃacos/efectos de los fármacos,
Miocitos CardÃacos/patologÃa,
Transducción de Señal,
Regulación hacia Arriba
Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed ...
Apoptosis/efectos de los fármacos,
Hipoxia de la Célula/efectos de los fármacos,
LÃnea Celular,
Proliferación Celular/efectos de los fármacos,
Citoprotección,
Glucósidos/farmacologÃa,
Miocitos CardÃacos/efectos de los fármacos,
Miocitos CardÃacos/metabolismo,
Miocitos CardÃacos/patologÃa,
ARN Largo no Codificante/efectos de los fármacos,
Transducción de Señal,
Estilbenos/farmacologÃa,
Regulación hacia Arriba/efectos de los fármacos
Inflammation plays an important role in the development of cardiovascular diseases (CVDs), suggesting that the immune system is a target of therapeutic interventions used for treating CVDs. This study evaluated mechanisms underlying inflammatory response and cardiomyocyte hypertrophy associated with bact...
ProteÃna Quinasa Tipo 2 Dependiente de Calcio Calmodulina/metabolismo,
Chaperonina 60/farmacologÃa,
Expresión Génica,
Inflamación/metabolismo,
Lipopolisacáridos/farmacologÃa,
Miocitos CardÃacos/efectos de los fármacos,
Miocitos CardÃacos/metabolismo,
Miocitos CardÃacos/patologÃa,
FN-kappa B/metabolismo,
ARN Interferente Pequeño,
Ratas Wistar,
Transducción de Señal/fisiologÃa,
Receptores Toll-Like/metabolismo
Abstract Background: Pioglitazone has been widely used as an insulin-sensitizing agent for improving glycemic control in patients with type 2 diabetes mellitus. However, cardiovascular risk and protective effects of pioglitazone remain controversial. Objectives: In this study, we investigated whether p...
Animales Recién Nacidos,
Apoptosis/efectos de los fármacos,
Hipertrofia/inducido quÃmicamente,
Hipertrofia/patologÃa,
Hipoglucemiantes/farmacologÃa,
Miocitos CardÃacos/efectos de los fármacos,
Miocitos CardÃacos/patologÃa,
Pioglitazona,
Ratas Sprague-Dawley,
Transducción de Señal/efectos de los fármacos,
Tiazolidinedionas/farmacologÃa,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/efectos de los fármacos
Abstract Purpose: To investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. Methods: Totally 12 female Wistar albino rats were divided into two groups, each consisting of 6 rats. Streptozotocin (60 mg/kg) was administ...
Antioxidantes/análisis,
Glucemia/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Gestacional,
Corazón/embriologÃa,
CardiopatÃas Congénitas/embriologÃa,
CardiopatÃas Congénitas/etiologÃa,
CardiopatÃas Congénitas/patologÃa,
Hiperglucemia/complicaciones,
MicroscopÃa,
Miocardio/patologÃa,
Miocitos CardÃacos/patologÃa,
Estrés Oxidativo,
Ratas Wistar,
Valores de Referencia,
Estreptozocina
Abstract Many non-invasive methods, such as imaging tests, have been developed aiming to add a contribution to existing studies in estimating patients' prognosis after myocardial injury. This prognosis is proportional to myocardial viability, which is evaluated in coronary artery disease and left ventric...
Enfermedad de la Arteria Coronaria/diagnóstico por imagen,
Enfermedad de la Arteria Coronaria/patologÃa,
Enfermedad de la Arteria Coronaria/fisiopatologÃa,
EcocardiografÃa/métodos,
Corazón/diagnóstico por imagen,
Imagen por Resonancia Magnética/métodos,
Infarto del Miocardio/diagnóstico por imagen,
Infarto del Miocardio/patologÃa,
Infarto del Miocardio/fisiopatologÃa,
Revascularización Miocárdica,
Miocardio/patologÃa,
Miocitos CardÃacos/patologÃa,
TomografÃa Computarizada por TomografÃa de Emisión de Positrones/métodos,
Pronóstico,
Supervivencia Tisular/fisiologÃa,
Disfunción Ventricular Izquierda/diagnóstico por imagen,
Disfunción Ventricular Izquierda/patologÃa
