Rosic, Vesna;
Tanaskovic, Irena;
Milosavljevic, Zoran;
Sazdanovic, Maja;
Rosic, Milenko;
Jakovljevic, Vladimir;
Nikolic-Turnic, Tamara;
Zornic, Nenad;
Nesic, Jelena;
Aleksic, Aleksandra;
Stankovic, Vesna.
SUMMARY: Atherosclerosis is a complex disease whose pathogenesis includes endothelial activation, accumulation of lipids in the subendothelium, formation of foam cells, fat bands and formation of atherosclerotic plaque. These complex mechanisms involve different cell populations in the intimate sub-endot...
Resumen: Introducción: Las células de la musculatura lisa vascular (CMLV) se caracterizan por mantener cierto grado de desdiferenciación, variando su fenotipo entre el contráctil y el secretor, de acuerdo con las necesidades del tejido, y el contráctil predominante en condiciones fisiológicas. Cual...
Smooth muscle cells (SMCs) are currently considered a central pivotal player in pathogenesis and development of atherosclerotic lesions. As consequence of vascular injury, SMCs migrate from the tunica media into the tunica intima layers where they contribute to neointimal formation by converting into foa...
BACKGROUND: Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people's life and health. In recent years, long non-coding RNA (lncRNA) has been found to be involved in gene expression regulation, but...
Currently, there is great clinical need for suitable synthetic grafts that can be used in vascular diseases. Synthetic grafts have been successfully used in medium and large arteries, however, their use in small diameter vessels is limited and presents a high failure rate. In this context, the aim of thi...
OBJECTIVES: In varicose veins, vascular smooth muscle cells (VSMCs) often shows phenotypic transition and abnormal proliferation and migration. Evidence suggests the FOXC2-Notch pathway may be involved in the pathogenesis of varicose veins. Here, this study aimed to explore the role of long non-coding RN...
Movimiento Celular/fisiología,
Proliferación Celular/fisiología,
Factores de Transcripción Forkhead/metabolismo,
Miocitos del Músculo Liso/metabolismo,
Vena Safena/metabolismo,
Miocitos del Músculo Liso/patología,
Vena Safena/patología,
Células Cultivadas,
Fenotipo,
Transducción de Señal,
Regulación hacia Arriba
SUMMARY OBJECTIVE: This study aims at investigating the expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/ tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary disease (COPD) and their relationships with pulmonary...
Estudios de Casos y Controles,
Volumen Espiratorio Forzado/fisiología,
Hematoxilina,
Inmunohistoquímica,
Pulmón/irrigación sanguínea,
Metaloproteinasa 9 de la Matriz/metabolismo,
Persona de Mediana Edad,
Miocitos del Músculo Liso/metabolismo,
Arteria Pulmonar/metabolismo,
Enfermedad Pulmonar Obstructiva Crónica/metabolismo,
Enfermedad Pulmonar Obstructiva Crónica/fisiopatología,
Valores de Referencia,
Inhibidor Tisular de Metaloproteinasa-1/metabolismo,
Receptor Toll-Like 4/metabolismo,
Remodelación Vascular,
Capacidad Vital/fisiología
Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a c...
Cromonas/farmacología,
Colágeno Tipo III/metabolismo,
Factor de Crecimiento del Tejido Conjuntivo/farmacología,
Fibronectinas/metabolismo,
Flavonoides/farmacología,
Sistema de Señalización de MAP Quinasas/efectos de los fármacos,
Células Cultivadas,
Colágeno Tipo III/genética,
Factor de Crecimiento del Tejido Conjuntivo/metabolismo,
Fibronectinas/genética,
Expresión Génica/efectos de los fármacos,
Regulación de la Expresión Génica,
Modelos Animales,
Miocitos del Músculo Liso/citología,
Miocitos del Músculo Liso/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Arteria Pulmonar/citología,
Ratas Sprague-Dawley
BACKGROUND: Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation. Here, the effect of exogenous S100A8 protein on the proliferation of ASMCs induced...
