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LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR-144-3p/FOXF1 axis in atherosclerosis

Liu, Yi; Cui, Xiyun; Wang, Cong; Zhao, Sihai.
Biol. Res; 53 (), 2020
BACKGROUND: Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people's life and health. In recent years, long non-coding RNA (lncRNA) has been found to be involved in gene expression regulation, but...
Factores de Transcripción Forkhead/genética, MicroARNs/genética, Miocitos del Músculo Liso/citología, ARN Largo no Codificante/genética, Aterosclerosis/genética, Apoptosis/genética, Proliferación Celular/genética, Músculo Liso Vascular/citología
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Poly(trimethylene carbonate-co-L-lactide) electrospun scaffolds for use as vascular grafts

Braghirolli, D I; Caberlon, B; Gamba, D; Petry, J F T C; Dias, M L; Pranke, P.
Braz. j. med. biol. res; 52 (8), 2019
Currently, there is great clinical need for suitable synthetic grafts that can be used in vascular diseases. Synthetic grafts have been successfully used in medium and large arteries, however, their use in small diameter vessels is limited and presents a high failure rate. In this context, the aim of thi...
Prótesis Vascular, Proliferación Celular, Células Cultivadas/citología, Dioxanos/química, Células Progenitoras Endoteliales/citología, Ensayo de Materiales, Células Madre Mesenquimatosas/citología, Miocitos del Músculo Liso/citología, Poliésteres/química, Andamios del Tejido/química
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Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells

Jia, Peng; Hu, Yu; Li, Gang; Sun, Yuqin; Zhao, Jian; Fu, Jie; Lu, Cuixia; Liu, Bin.
Acta cir. bras; 32 (5), 2017
Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a c...
Cromonas/farmacología, Colágeno Tipo III/metabolismo, Factor de Crecimiento del Tejido Conjuntivo/farmacología, Fibronectinas/metabolismo, Flavonoides/farmacología, Sistema de Señalización de MAP Quinasas/efectos de los fármacos, Células Cultivadas, Colágeno Tipo III/genética, Factor de Crecimiento del Tejido Conjuntivo/metabolismo, Fibronectinas/genética, Expresión Génica/efectos de los fármacos, Regulación de la Expresión Génica, Modelos Animales, Miocitos del Músculo Liso/citología, Miocitos del Músculo Liso/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, Proteínas Proto-Oncogénicas c-akt/metabolismo, Arteria Pulmonar/citología, Ratas Sprague-Dawley
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