BACKGROUND: Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (...
Abstract Objective Endometriosis causes a decrease in oocyte quality. However, this mechanism is not fully understood. The present study aimed to analyze the effect of endometriosis on cumulus cell adenosine triphosphate ATP level, the number of mitochondria, and the oocyte maturity level. Methods A tr...
SUMMARY: Gastrin plays a vital role in the development and progression of gastric cancer (GC). Its expression is up-regulated in GC tissues and several GC cell lines. Yet, the underlying mechanism remains to be investigated. Here, we aim to investigate the role and mechanism of gastrin in GC proliferatio...
Gastrinas/metabolismo,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Apoptosis,
Especies Reactivas de Oxígeno,
Anexina A2/metabolismo,
Proliferación Celular,
FN-kappa B,
Mitocondrias/patología,
Citometría de Flujo,
Técnica del Anticuerpo Fluorescente,
Espectrometría de Masas,
Línea Celular Tumoral,
Inmunoprecipitación,
Carcinogénesis
Purpose: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardiopro...
Abrigo, Johanna;
Olguín, Hugo;
Tacchi, Franco;
Orozco-Aguilar, Josué;
Valero-Breton, Mayalen;
Soto, Jorge;
Castro-Sepúlveda, Mauricio;
Elorza, Alvaro A;
Simon, Felipe;
Cabello-Verrugio, Claudio.
BACKGROUND: Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besides, a mouse model of cholestasis-induced sarcopenia was characterised by increased ...
This scoping review aimed to synthesize the best available evidence of the associations between molecular and genetic markers of mitochondrial metabolism and fatigue in human adults. The research question guiding this review was, “Are there potential relationships between mitochondrial metabolism marke...
Abstract The prolonged entry of large amounts of calcium into the mitochondria through the mitochondrial calcium uniporter complex (MCUC) may cause the permeability transition pore (mPTP) to open, which contributes to the pathogenesis of several diseases. Tissue-specific differences in mPTP opening due t...
Poro de Transición de la Permeabilidad Mitocondrial/análisis,
Cerebro/anomalías,
Ratones,
1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina/efectos adversos,
Calcio/agonistas,
Corteza Renal,
Encéfalo,
Mitocondrias
Abstract Ischemia/reperfusion (IR) injury leads to overproduction of Reactive Oxygen Species (ROS), and disrupts membrane potential that contributes to cell death. The aim of this study was to determine if naringin (NAR), trimetazidine (TMZ) or their combination, protect the kidney mitochondrial from IR ...
BACKGROUND: Retinal neurodegeneration is induced by a variety of environmental insults and stresses, but the exact mechanisms are unclear. In the present study, we explored the involvement of cytosolic mitochondrial DNA (mtDNA), resulting in the cGAS-STING dependent inflammatory response and apoptosis in...
Zhang, Yan;
Yin, Wei-hua;
Yang, Fan;
An, Yun-qiang;
Zhou, Wei;
Yu, Hui;
Xie, Hong;
Zhang, Yan-ling;
Zhu, Yue;
Shen, Xiang-chun;
Tian, Ruiqing.
Resumo Fundamento: A doença cardiovascular é a principal causa de morte em todo o mundo. A apoptose mediada por hipóxia em cardiomiócitos é uma das principais causas de distúrbios cardiovasculares. O tratamento com a proteína do fator de crescimento endotelial vascular (VEGF, do inglês vascular ...
