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Development of a species-specific PCR assay for authentication of Agkistrodon acutus based on mitochondrial cytochrome b gene

Li, Yingnuo; Yanshuang, Wang; Mingcheng, Li; Lihua, Zhang; Guang Xin, Yuan.
Electron J Biotechnol; 49 (), 2021
BACKGROUND: Agkistrodon acutus, a traditional Chinese medicine, clinically used in the treatment of rheumatism, tumor, and cardiovascular and cerebrovascular diseases. Due to the unique medicinal value and the difficulty of artificial breeding of Agkistrodon acutus, the supply of Agkistrodon acutus on th...
Agkistrodon/genética, Citocromos b/genética, Mitocondrias/genética, Reacción en Cadena de la Polimerasa/métodos, Medicina Tradicional China, Especificidad de la Especie, ADN/análisis, Serpientes, Clonación Molecular
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CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cells

Wang, Lamei; Ma, Sen; Ding, Qiang; Wang, Xiaolong; Chen, Yulin.
Electron. j. biotechnol; 40 (), 2019
Background: Myostatin (MSTN) negatively regulates muscle mass and is a potent regulator of energy metabolism. However, MSTN knockout have affect mitochondrial function. This research assessed the mitochondrial energy metabolism of Mstn−/+ KO cells, and wondered whether the mitochondria biogenesis are a...
Mitocondrias/genética, Mitocondrias/metabolismo, Edición Génica, Sistemas CRISPR-Cas, Miostatina/genética, Diferenciación Celular, Mioblastos/metabolismo, Mioblastos/citología, MicroARNs, Proliferación Celular, Immunoblotting, Citometría de Flujo, Biogénesis de Organelos, Músculo Esquelético/citología, Músculo Esquelético/metabolismo
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The advances and new technologies for the study of mitochondrial diseases

Bianco, Bianca; Montagna, Erik.
Einstein (Säo Paulo); 14 (2), 2016
ABSTRACT Genetic mitochondrial disorders are responsible for the most common inborn errors of metabolism, caused by mutations in either nuclear genes or in mitochondrial DNA. This article presents the prokaryotic origin of the organelle and the relation between nuclear and mitochondrial genomes, as well ...
Enfermedades Mitocondriales, Terapia de Reemplazo Mitocondrial, Mitocondrias/genética, Mitocondrias/fisiología, Enfermedades Mitocondriales/diagnóstico, Enfermedades Mitocondriales/genética, Enfermedades Mitocondriales/prevención & control, Terapia de Reemplazo Mitocondrial/ética, Diagnóstico Preimplantación
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