SUMMARY: In this study we aimed to examine the effect of novel vasodilatory drug Riociguat co-administration along resveratrol to recover neurodegeneration in experimental stroke injury. For that purpose, thirty-five adult female rats were divided into five groups (Control, MCAO, MCAO + R, MCAO + BAY, MC...
Accidente Cerebrovascular/tratamiento farmacológico,
Pirazoles/administración & dosificación,
Pirimidinas/administración & dosificación,
Activadores de Enzimas/administración & dosificación,
Resveratrol/administración & dosificación,
Apoptosis/efectos de los fármacos,
Inflamación,
Modelos Animales,
Guanilato Ciclasa/efectos de los fármacos,
Fármacos Neuroprotectores,
Ensayo de Inmunoadsorción Enzimática,
Inmunohistoquímica,
Quimioterapia Combinada,
Accidente Cerebrovascular/patología,
Arteria Cerebral Media,
Arteriopatías Oclusivas,
Interleucina-1beta/análisis,
Interleucina-6/análisis
Objective: To analyze the muscle mass and cross-sectional area of the muscular fiber of the hemiparetic soleus in an animal model, in order to identify the muscular adaptations that occur in ischemic stroke.Method: Twelve Rattus norvegicus were divided into 2 groups: stroke group (n=6) and control group ...
Accidente Cerebrovascular Isquémico,
Accidente Cerebrovascular,
Accidentes,
Heridas y Lesiones,
Grupos Control,
Métodos,
Músculo Esquelético,
Músculos,
Pacientes,
Investigación,
Predicción,
Modelos Animales
Razaque, R;
Raza, A. R;
Irshad, M;
Rubab, S. L;
Batool, S;
Nisar, B;
Akram, Z;
Akhtar, M. T;
Qadir, R;
Siddique, Abu Bakar;
Siddique, Farzana;
Saadia, M.
Due to the severe side effects revealed by most of the currently used antidiabetic medicines, search for finding new and safe drugs to manage diabetes is continued. Naphthoquinones possessing strong antioxidant properties have been employed as candidates for diabetes therapy. Present study is aimed at fi...
Purpose: This study aimed to evaluate a new therapeutic option for the spasticity using ultrasound neuromodulation in an animal model of spastic cerebral palsy. Methods: Thirty-two adult male Wistar rats were randomly distributed in: negative control (NC); positive control (PC); untreated model (UTM); a...
Purpose: This study aimed to introduce and evaluate two new microvascular anastomosis techniques compared to the conventional method in a rat renal transplant model. Methods: Using a Fisher-to-Lewis rat kidney transplantation model, the renal artery anastomosis was performed using the interrupted (I) su...
A família dos receptores de cininas compreende dois subtipos, sendo o B1R aquele
em tem como um de seus agonistas fisiológicos a des-Arg9
-BK (DBK). O receptor B1
tem baixa expressão ou está até mesmo ausente em condições fisiológicas normais,
podendo ser induzido por vários estímulos, como o p...
Introdução: A administração de fluidos é muitas vezes realizada no Acidente Vascular
Encefálico isquêmico (AVEi) agudo. Permanecem controvérsias em relação ao efeito de
diferentes concentrações de sódio em fluidos administrados após AVEi, bem como seu
impacto em órgãos a distância. Nosso...
Abstract Objective Although autologous bone grafting is the most widely used treatment for bone defects, the most effective preparation remains unclear. This animal study aimed to compare different autologous bone grafting preparation for the treatment of rats calvaria critical bone defect. Methods 122...
Abstract Objective To reproduce in an animal model the surgical technique of Masquelet used in the treatment of critical bone defects and to analyze the characteristics of the membrane formed around the bone cement. Methods A 10mm critical defect was created in the femoral shaft of 21 Sprague-Dawley ra...
SUMMARY: Experimental healing studies in humans are complex and difficult to replicate in vitro. Hence, animal models are needed to study the different stages involved. The guinea pig (Cavia porcellus) is a model close to human physiology, including the lack of vitamin C synthesis, a precursor of collage...
