LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Acidic Environment Induces Pyroptosis of NLRP3 Inflammatory Vesicle-Mediated Nucleus Pulposus Cells Through Up-Regulation of POSTN Expression

Zhang, Lin; Tao, Jingwen; Lu, Xiaoqin; Yu, Huaixi; Cai, Feng; Chen, Xiaogang.

Int. j. morphol; 41 (6), 2023

SUMMARY: Intervertebral disc degeneration (IVDD) is induced by nucleus pulposus (NP) dysfunction as a result of massive loss of NP cells. It has been reported that the acidic microenvironment of the intervertebral disc (IVD) can induce NP cell pyroptosis, and that up-regulation of periostin (POSTN) expre...

Ácidos/química, Ambiente, Degeneración del Disco Intervertebral, Núcleo Pulposo/fisiopatología, Moléculas de Adhesión Celular/metabolismo, Núcleo Pulposo/citología, Proteína con Dominio Pirina 3 de la Familia NLR, Ratas Sprague-Dawley, Moléculas de Adhesión Celular/genética, Reacción en Cadena en Tiempo Real de la Polimerasa, Western Blotting, Ensayo de Inmunoadsorción Enzimática, Supervivencia Celular, d0123330

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Aqueous humor heat-shock protein 70, periostin, and irisin levels in patients with pseudoexfoliation syndrome

Güler, Mete; Aydin, Süleyman; Urfalioglu, Selma; Yardim, Meltem.

Arq. bras. oftalmol; 83 (5), 2020

ABSTRACT Purpose: To measure humor heat-shock protein 70, periostin, and irisin levels in patients with pseudoexfoliation syndrome and cataract (without glaucoma), and compare them with those of patients with cataract but without pseudoexfoliation. Methods: We examined 31 eyes of 31 patients with pseud...

Catarata, Moléculas de Adhesión Celular, Síndrome de Exfoliación, Fibronectinas, Glaucoma, Proteínas HSP70 de Choque Térmico, Humor Acuoso, Moléculas de Adhesión Celular/metabolismo, Ensayo de Inmunoadsorción Enzimática, Síndrome de Exfoliación/metabolismo, Fibronectinas/metabolismo, Proteínas HSP70 de Choque Térmico/metabolismo

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MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells

Cao, Danxia; Zhu, Han; Zhao, Qian; Huang, Jianming; Zhou, Cixiang; He, Jianrong; Liang, Yongjun.

Biol. Res; 53 (), 2020

BACKGROUND: Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated into almost all...

Neoplasias de la Mama/genética, MicroARNs/genética, MicroARNs/fisiología, Invasividad Neoplásica/genética, Moléculas de Adhesión Celular/genética, Moléculas de Adhesión Celular/metabolismo, Línea Celular Tumoral, Regulación Neoplásica de la Expresión Génica, Proteínas de la Membrana, Recurrencia Local de Neoplasia, Proteínas de Unión al ARN

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Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice

Jia, YL; Fu, ZX; Zhang, BH; Jia, YJ.

Braz. j. med. biol. res; 50 (6), 2017

Down syndrome cell adhesion molecule (DSCAM) is located within the Down syndrome critical region of chromosome 21. DSCAM is a broadly expressed neurodevelopmental protein involved in synaptogenesis, neurite outgrowth, and axon guidance. We previously demonstrated DSCAM overexpression in the cortex of amy...

Factores de Edad, Precursor de Proteína beta-Amiloide/genética, Encéfalo/metabolismo, Moléculas de Adhesión Celular/metabolismo, Modelos Animales de Enfermedad, Síndrome de Down/metabolismo, Genotipo, Hipocampo/metabolismo, Discapacidades para el Aprendizaje/metabolismo, Trastornos de la Memoria/metabolismo, Ratones Endogámicos C57BL, Ratones Transgénicos

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