Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Braz. J. Psychiatry (São Paulo, 1999, Impr.); 40 (4), 2018
Objective: Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in ani...