SUMMARY: Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote tumor cell proliferation, migration, and invasion. However, the role of MALAT1 in gastric cancer (GC) is still unclear. We aimed to investigate the corre...
Neoplasias Gástricas/patología,
ARN Largo no Codificante,
Proliferación Celular,
Factor A de Crecimiento Endotelial Vascular,
Serina-Treonina Quinasas TOR,
Transducción de Señal,
Neoplasias Gástricas/genética,
ARN/genética,
Western Blotting,
Genes Reporteros,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación Neoplásica de la Expresión Génica,
Movimiento Celular,
Apoptosis
Concentrações aumentadas de tecido adiposo corporal observadas no sobrepeso e obesidade, podem gerar a produção de diversos mediadores inflamatórios com ação direta ou indireta em influenciar a capacidade de proliferação e diferenciação das células hematopoéticas e, consequentemente, a compl...
SUMMARY: Keloid scar is a unique benign fibroproliferative tumor of the human skin. Previously, it was reported that early growth response 1 (EGR1), a transcription factor, promotes keloid fibrosis; however, the mechanism by which EGR1 modulates keloid formation was not elaborated. In this research, the ...
Fibroblastos,
Queloide/patología,
Transfección,
Queloide/genética,
MicroARNs/fisiología,
Proteína 1 de la Respuesta de Crecimiento Precoz,
Apoptosis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Proliferación Celular,
Movimiento Celular,
Regulación hacia Abajo,
d0347410,
Análisis de Secuencia de ARN,
Cicatrización de Heridas
SUMMARY: We investigated the expression and clinical significance of miR-15b-5p in clear cell renal cell carcinoma (RCC) through bioinformatics analysis and experimental verification. The differentially expressed miRNAs were screened in the GEO database. Venn diagram showed that there were 5 up-regulated...
Neoplasias Renales/patología,
Neoplasias Renales/genética,
Carcinoma de Células Renales/patología,
Carcinoma de Células Renales/genética,
MicroARNs,
Metástasis de la Neoplasia,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Invasividad Neoplásica,
Biología Computacional,
Análisis de Supervivencia,
Movimiento Celular
BACKGROUND: Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these problems. Despite considerable antitumor properties of Oxaliplatin (Oxa), the limitin...
BACKGROUND: The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULINK protein is involved in vasculogenesis, especially venous formation. METHODS: In t...
BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and ischemic tissue ...
Abstract Rheumatoid arthritis (RA) is an inflammatory disease that utilizes nonbiologic and biologic drugs for appropriate disease management. However, high cost, adverse effects, reduced effectiveness, and risk of infection have stimulated the search for safer and more efficacious therapeutic strategies...
The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells. This study also explored the potential anti-cancer mechanism of melittin in NSCLC cells. The results demonstrated that melittin suppre...
Apoptosis,
Factor Apoptótico 1 Activador de Proteasas,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Caspasa 3,
Línea Celular Tumoral,
Movimiento Celular,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/genética,
Sistema de Señalización de MAP Quinasas,
Meliteno/farmacología,
Invasividad Neoplásica,
Factor de Crecimiento Transformador beta/metabolismo
Abstract Objective Oral squamous cell carcinoma (OSCC) is one of the common type of cancer that leads to death; and is becoming a global concern. Due to the lack of efficient chemotherapeutic agents for patients with oral cancer, the prognosis remains poor. 6-shogaol, a bioactive compound of ginger, ha...
