Results: 7

MicroRNA-629-5p promotes osteosarcoma proliferation and migration by targeting caveolin 1

Gao, Chunsheng; Gao, Jun; Zeng, Ge; Yan, Huichao; Zheng, Junhua; Guo, Weichun.

Braz. j. med. biol. res; 54 (6), 2021

Osteosarcoma is a highly malignant tumor that occurs in the bone. Previous studies have shown that multiple microRNAs (miRNAs) regulate the development of osteosarcoma. This study aimed to explore the role of miR-629-5p and its target gene, caveolin 1 (CAV1), in osteosarcoma development. To analyze the e...

Neoplasias Óseas/genética, Caveolina 1/genética, Línea Celular Tumoral, Movimiento Celular/genética, Proliferación Celular/genética, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, Osteosarcoma/genética

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Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer

Fu, Ping; Lin, Liangqing; Zhou, Hui; Zhao, Sijun; Jie, Zhigang.

Braz. j. med. biol. res; 54 (8), 2021

Recently, an increasing number of studies have reported that dysregulation of circular RNA (circRNA) expression plays critical roles in the progression of several cancers, including colorectal cancer (CRC). However, the detailed molecular mechanisms of circRNAs involvement in CRC remain largely unknown. ...

Línea Celular Tumoral, Movimiento Celular/genética, Proliferación Celular/genética, Neoplasias Colorrectales/genética, ARN Helicasas DEAD-box, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, ARN Circular

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Low miR-1273a expression predicts poor prognosis of colon cancer and facilitates tumor cell proliferation, migration, and invasion

Sun, Lei; Zhou, Xin; Jiang, Qian; Zhuang, Yiping; Li, Dongzheng.

Braz. j. med. biol. res; 54 (2), 2021

MicroRNAs (miRNAs) have been indicated to be frequently dysregulated in various cancers and promising biomarkers for colon cancer. The present study aimed to assess the prognostic significance and biological function of miR-1273a in colon cancer. The expression levels of miR-1273a was estimated using qua...

Biomarcadores de Tumor/genética, Movimiento Celular/genética, Proliferación Celular/genética, Neoplasias del Colon/diagnóstico, Neoplasias del Colon/genética, MicroARNs/genética, Invasividad Neoplásica

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Long non-coding RNA DLGAP1-AS1 promotes the progression of gastric cancer via miR-515-5p/MARK4 axis

Li, Liping; Lai, Qingjun; Zhang, Manman; Jia, Jun.

Braz. j. med. biol. res; 54 (8), 2021

Long non-coding RNA (lncRNA) is an essential regulator of carcinogenesis and cancer progression. In the study, we explored the role of lncRNA DLGAP1-AS1 in gastric cancer (GC). qRT-PCR was carried out to detect DLGAP1-AS1 expression in GC tissues and cell lines. CCK-8 assay, EdU assay, and transwell expe...

Línea Celular Tumoral, Movimiento Celular/genética, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, Proteínas Serina-Treonina Quinasas, ARN Largo no Codificante/genética, Neoplasias Gástricas/genética

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Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p

Xu, Bingnv; Geng, Xiaofang; Liu, Xiaodan; Liu, Ying.

Braz. j. med. biol. res; 53 (12), 2020

Preeclampsia (PE) is a complex pregnancy syndrome. Convincing evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of PE. This research mainly investigated the mechanism of family with sequence similarity 99 member A (FAM99A) in PE. The expressions of FAM99A, miR-134-5p...

Movimiento Celular/genética, MicroARNs, Preeclampsia/genética, ARN Largo no Codificante/genética, Trofoblastos

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lncRNA CCAT1 promotes bladder cancer cell proliferation, migration and invasion

Zhang, Caixiang; Wang, Wenying; Lin, Jun; Xiao, Jing; Tian, Ye.

Int. braz. j. urol; 45 (3), 2019

ABSTRACT Objective: To study the expression patterns of long noncoding RNA (lncRNA) colon cancer-associated transcript 1 (CCAT1) and the changes in cell proliferation, apoptosis, migration and invasion induced by silencing CCAT1 in bladder cancer cells. Materials and Methods: The expression levels of C...

Línea Celular Tumoral, Movimiento Celular/genética, Proliferación Celular/genética, Regulación hacia Abajo, Citometría de Flujo, Expresión Génica, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, ARN Largo no Codificante/análisis, ARN Interferente Pequeño, Reacción en Cadena en Tiempo Real de la Polimerasa, Sincalida/análisis, Factores de Tiempo, Regulación hacia Arriba, Neoplasias de la Vejiga Urinaria/genética, Neoplasias de la Vejiga Urinaria/patología, Cicatrización de Heridas/genética

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Estudo genético-clínico e citogenético-molecular de pacientes portadores da seqüencia da lisencefalia isolada

Galera, Marcial Francis.

A lisencefalia clássica (LC) é uma malformação cerebral caracterizada por uma superfície cerebral lisa devido a um distúrbio na migração neuronal. A LC tem sido observada em associação com a Síndrome de Miller-Dieker (SMD) e a Seqüência da Lisencefalia Isolada (SLI). A literatura mostra que ...

Cerebro/anomalías, Movimiento Celular/genética, Hibridación Fluorescente in Situ