ABSTRACT Purpose: To evaluate the effects of sucralfate enemas in tissue contents of E-cadherin and ?-catenin in an experimental diversion colitis. Methods: Thirty-six male Wistar rats were submitted to a proximal colostomy and a distal mucous fistula. They were allocated into three groups: first group...
Li, Musheng;
Zhao, Junhong;
Cao, Meiwan;
Liu, Ruitao;
Chen, Guanhua;
Li, Songyu;
Xie, Yuanwen;
Xie, Jing;
Cheng, Yang;
Huang, Ling;
Su, Mingmin;
Xu, Yuxin;
Zheng, Mingyue;
Zou, Kejian;
Geng, Lanlan;
Xu, Wanfu;
Gong, Sitang.
BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...
Células Epiteliales/metabolismo,
Mucosa Intestinal/metabolismo,
Mastocitos/metabolismo,
MicroARNs/metabolismo,
Células CACO-2/citología,
Claudinas/metabolismo,
Exosomas/metabolismo,
Enfermedades Inflamatorias del Intestino/metabolismo,
Ocludina/metabolismo,
Proteína de la Zonula Occludens-1/metabolismo,
Células Cultivadas,
Biología Computacional,
Permeabilidad,
Análisis de Matrices Tisulares
Akamatsu, Flávia Emi;
Fontes, Luiz Gustavo;
Itezerote, Ana Maria;
Saleh, Samir;
Teodoro, Walcy Paganelli Rosolia;
Artifon, Everson;
Hojaij, Flávio;
Andrade, Mauro;
Pereira, José Aires;
Martinez, Carlos Augusto Real;
Jacomo, Alfredo Luiz.
Abstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stom...
Abstract Objective: To describe the current indicators of environmental enteric dysfunction and its association with linear growth deficit and the height-for-age anthropometric indicator. Data sources: Narrative review with articles identified in PubMed and Scopus databases using combinations of the fo...
Abstract Purpose: To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats. Methods: The animals were divided into 4 groups: CTL, H/R, H/R+Td and M+Td. The newborn rats allocated in groups ...
Animales Recién Nacidos,
Hipoxia/metabolismo,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/patología,
Peroxidación de Lípido,
Malondialdehído/análisis,
Nitratos/análisis,
Nitritos/análisis,
Estrés Oxidativo/efectos de los fármacos,
Oxígeno/metabolismo,
Inhibidores de Fosfodiesterasa 5/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Tadalafilo/farmacología,
Factores de Tiempo
Abstract Purpose: To evaluate the inflammatory reaction and measure the content of mucins, in the colonic mucosa without fecal stream submit to intervention with mesalazine. Methods: Twenty-four rats were submitted to a left colostomy and a distal mucous fistula and divided into two groups according t...
Antiinflamatorios no Esteroideos/farmacología,
Antiinflamatorios no Esteroideos/uso terapéutico,
Colitis/patología,
Colitis/prevención & control,
Colon/efectos de los fármacos,
Colon/metabolismo,
Colon/patología,
Colostomía,
Enema/métodos,
Heces,
Tránsito Gastrointestinal,
Histocitoquímica,
Procesamiento de Imagen Asistido por Computador,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/patología,
Mesalamina/farmacología,
Mesalamina/uso terapéutico,
Mucinas/análisis,
Mucinas/efectos de los fármacos,
Estrés Oxidativo,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
ABSTRACT BACKGROUND: Increased angiogenetic activity in inflammatory bowel disease (IBD) has been shown in previous studies. The aim of this study was to evaluate the relationship of serum vascular endothelial growth factor (VEGF) and endostatin levels with clinical features and mucosal expression in p...
Estudios de Casos y Controles,
Colitis Ulcerosa/sangre,
Colitis Ulcerosa/patología,
Estudios Transversales,
Endostatinas/sangre,
Ensayo de Inmunoadsorción Enzimática,
Mucosa Intestinal/irrigación sanguínea,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/patología,
Síndrome del Colon Irritable/sangre,
Síndrome del Colon Irritable/patología,
Factores de Crecimiento Endotelial Vascular/sangre,
Factores de Crecimiento Endotelial Vascular/metabolismo
Abstract Objective: To study fructose malabsorption in children and adolescents with abdominal pain associated with functional gastrointestinal disorders. As an additional objective, the association between intestinal fructose malabsorption and food intake, including the estimated fructose consumption, ...
Dolor Abdominal/metabolismo,
Dolor Abdominal/fisiopatología,
Estatura/fisiología,
Peso Corporal/fisiología,
Pruebas Respiratorias,
Ingestión de Alimentos/fisiología,
Fermentación/fisiología,
Fructosa/metabolismo,
Intolerancia a la Fructosa/metabolismo,
Hidrógeno/metabolismo,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/fisiopatología,
Lactulosa/metabolismo,
Síndromes de Malabsorción/metabolismo,
Síndromes de Malabsorción/fisiopatología,
Valores de Referencia,
Estadísticas no Paramétricas,
Factores de Tiempo
El objetivo de esta revisión fue exponer el conocimiento actual sobre la relación existente entre dietas altas en grasa (DAG), alteraciones morfológicas de la mucosa intestinal, efectos inflamatorios y cáncer intestinal. Las DAG inicialmente producen aumento de la microbiota patógena, lo que reduce ...
Dieta Alta en Grasa/efectos adversos,
Grasas de la Dieta/efectos adversos,
Microbioma Gastrointestinal/efectos de los fármacos,
Inflamación/etiología,
Mucosa Intestinal/efectos de los fármacos,
Uniones Estrechas/efectos de los fármacos,
Ácidos y Sales Biliares/metabolismo,
Tracto Gastrointestinal/microbiología,
Inflamación/metabolismo,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/microbiología,
Citocinas/metabolismo
Reducing nitrogen nutrients concentration in dairy food is economic for pig industry. Here, we used finishing pig as model to investigate the effect on colon mucosal barrier and nutrients absorption after reducing crude protein (CP) in dietary from 16 % to 13 %. The results showed that crypt depth, cells...
