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Mycobacterium tuberculosis promotes genomic instability in macrophages

Castro-Garza, Jorge; Luévano-Martínez, Miriam Lorena; Villarreal-Treviño, Licet; Gosálvez, Jaime; Fernández, José Luis; Dávila-Rodríguez, Martha Imelda; García-Vielma, Catalina; González-Hernández, Silvia; Cortés-Gutiérrez, Elva Irene.
Mem. Inst. Oswaldo Cruz; 113 (3), 2018
BACKGROUND Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES To evaluate the genomic instability o...
Inestabilidad Genómica/genética, Daño del ADN, Roturas del ADN, Mycobacterium tuberculosis/fisiología, Hibridación Fluorescente in Situ
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Bacterial immunostat: mycobacterium tuberculosis lipids and their role in the host immune response

Queiroz, Adriano; Riley, Lee W.
Rev. Soc. Bras. Med. Trop; 50 (1), 2017
Abstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an inf...
Pared Celular/metabolismo, Pared Celular/fisiología, Inmunidad Innata, Metabolismo de los Lípidos, Lípidos/fisiología, Lípidos de la Membrana/fisiología, Proteínas de Transporte de Membrana, Mycobacterium tuberculosis/metabolismo, Mycobacterium tuberculosis/fisiología
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Evaluation of the role of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer of epithelial cells

Ramsugit, Saiyur; Pillay, Balakrishna; Pillay, Manormoney.
Braz. j. infect. dis; 20 (2), 2016
Abstract This study was undertaken in order to assess the involvement of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer in the M. tuberculosis-epithelial cell interaction. A MTP-deficient strain of M. tuberculosis demonstrated a significant reduction of 69.39% (p = 0.0...
Proteínas Bacterianas/metabolismo, Proteínas Bacterianas/fisiología, Adhesión Celular/fisiología, Citocinas/inmunología, Células Epiteliales/microbiología, Fimbrias Bacterianas/fisiología, Mycobacterium tuberculosis/inmunología, Mycobacterium tuberculosis/fisiología
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Use of the Ogawa-Kudoh method to isolate mycobacteria in a tuberculosis reference laboratory in northwestern Paraná, Brazil

Silva, Fernanda Schaefer Borges da; Castilho, Aline Lemes; Maltempe, Flaviane Granero; Pina, Rosangela Zampieri; Takao, Elisa Keiko Hirayama; Siqueira, Vera Lúcia Dias; Cardoso, Rosilene Fressatti; Caleffi-Ferracioli, Katiany Rizzieri.
Braz. j. pharm. sci; 49 (3), 2013
Culturing is the gold standard method for confirming a diagnosis of tuberculosis (TB). The Brazilian Ministry of Health recently proposed the use of the Ogawa-Kudoh method for sputa cultures to detect Mycobacterium tuberculosis. The aim of the present study was to evaluate 8 years of using the Ogawa-Kudo...
Micobacterias no Tuberculosas/clasificación, Mycobacterium tuberculosis/fisiología, Tuberculosis/clasificación, Esputo/22063, Métodos
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