Results: 5

Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells

Mem. Inst. Oswaldo Cruz; 113 (6), 2018
BACKGROUND Streptococcus agalactiae can causes sepsis, pneumonia, and meningitis in neonates, the elderly, and immunocompromised patients. Although the virulence properties of S. agalactiae have been partially elucidated, the molecular mechanisms related to reactive oxygen species (ROS) generation in inf...

Hyperbaric oxygenation and the genic expression related to oxidative stress in the heart of mice during intestinal ischemia and reperfusion

Acta cir. bras; 32 (11), 2017
Abstract Purpose: To investigate the effects of hyperbaric oxygenation (HBO) on intestinal ischemia and reperfusion (IR) injury, we evaluated the expression of 84 genes related to oxidative stress and the antioxidant response in mouse hearts. Methods: Four groups were subjected to 60 minutes of intest...

Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries

Arq. bras. cardiol; 107 (5), 2016
Abstract Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. Objective: To investigate whether acute ethanol intake activates the vascular RhoA/Rho ki...

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Biol. Res; 48 (), 2015
BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced b...

Sistema enzimático gerador de peróxido de hidrogênio: NADPH oxidase na tireóide humana
Enzimatic system generator of hydrogen peroxide: NADPH oxidase in human thyroid

No presente estudo avaliamos a atividade geradora de peróxido de hidrogênio (H 2 O 2 ) em frações particuladas de tireóides suínas e humanas. Inicialmente, analisamos as propriedades bioquímicas da NADPH-oxidase - enzima geradora de H 2 O 2 - localizada na membrana apical da célula tireóidea su...