LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Small Molecules Accelerate Skin Wound Healing: Shikonin Efficacy and Mechanism of Action in Mice

SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...

Terpinen-4-ol, tyrosol, and ß-lapachone as potential antifungals against dimorphic fungi

Brilhante, Raimunda Sâmia Nogueira; Caetano, Érica Pacheco; Lima, Rita Amanda Chaves de; Marques, Francisca Jakelyne de Farias; Castelo-Branco, Débora de Souza Collares Maia; Melo, Charlline Vládia Silva de; Guedes, Glaucia Morgana de Melo; Oliveira, Jonathas Sales de; Camargo, Zoilo Pires de; Moreira, José Luciano Bezerra; Monteiro, André Jalles; Bandeira, Tereza de Jesus Pinheiro Gomes; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa.

Braz. j. microbiol; 47 (4), 2016

Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22) and Histoplasma capsulatum in both filamentous (n = 40) and yeast phases (n = 13), using the broth dilution method...

Antifúngicos/farmacología, Hongos/efectos de los fármacos, Naftoquinonas/farmacología, Alcohol Feniletílico/análogos & derivados, Terpenos/farmacología, Permeabilidad de la Membrana Celular/efectos de los fármacos, Ergosterol/metabolismo, Hongos/clasificación, Hongos/metabolismo, Pruebas de Sensibilidad Microbiana, Presión Osmótica, Alcohol Feniletílico/farmacología

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