Suthovski, Gabriela;
Catarina, Alcione Santa;
Perin, Diana Paula;
Mainardes, Rubiana Mara;
Starikoff, Karina Ramirez;
Gallina, André Lazarin;
Azevedo, Maiara Garcia Blagitz;
Dalmolin, Fabíola;
Cervo, Luciana Velasques;
Benvegnú, Dalila Moter.
Abstract Bovine infectious mastitis is largely resistant to antibacterial treatment, mainly due to mechanisms of bacterial resistance in the biofilms formed by Staphylococcus aureus. Melaleuca (MEO) and citronella essential oils (CEO) are promising agents for reducing or eliminating biofilms. Free melale...
Anti-inflammatory drugs are being utilized to treat cancer because of its inflammatory microenvironment. Objective: The objective of this study is to investigate the antioxidant potential of indomethacin and its genotoxicity, since free or loaded in polymeric nanocapsules using MCF-7 (human breast cancer...
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide, being the ischemic heart disease responsible for 85% of deaths. Atherosclerosis is a chronic inflammation of the arteries that underlies ischemic forms of CVD and involves the innate and adaptive immune systems, from initial fatty ...
Ácidos Docosahexaenoicos/análisis,
Nanocápsulas/análisis,
Aterosclerosis/patología,
Placa Aterosclerótica/metabolismo,
Antiinflamatorios/administración & dosificación,
Arterias/anomalías,
Causalidad,
Enfermedades Cardiovasculares/clasificación,
Estrategias de Salud,
Molécula-1 de Adhesión Celular Endotelial de Plaqueta,
Nanopartículas,
Preparaciones Farmacéuticas/análisis
Introduction: Anti-inflammatory drugs are being utilized to treat cancer because of its inflammatory microenvironment. Objective: The objective of this study is to investigate the antioxidant potential of indomethacin and its genotoxicity, since free or loaded in polymeric nanocapsules using MCF-7 (human...
Antihelmínticos/farmacología,
Nanocápsulas/administración & dosificación,
Monoterpenos/farmacología,
Enfermedades de las Ovejas/parasitología,
Infecciones por Nematodos/veterinaria,
Tracto Gastrointestinal/parasitología,
Ovinos/parasitología,
Antihelmínticos/toxicidad,
Nanocápsulas/toxicidad,
Monoterpenos/toxicidad,
Ratas Wistar/sangre,
Ratones,
Resistencia a Medicamentos/efectos de los fármacos,
Haemonchus/aislamiento & purificación,
Haemonchus/efectos de los fármacos,
Bencimidazoles/farmacología,
Levamisol/farmacología,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Antihelmínticos/uso terapéutico,
Nanocápsulas/uso terapéutico,
Monoterpenos/uso terapéutico,
Enfermedades de las Ovejas/tratamiento farmacológico,
Infecciones por Nematodos/tratamiento farmacológico,
Helmintiasis Animal/tratamiento farmacológico,
Hemoncosis/tratamiento farmacológico,
Recuento de Huevos de Parásitos,
Pruebas de Sensibilidad Parasitaria,
Pruebas de Toxicidad
Abstract Cilostazol (CLZ) is a phosphodiesterase III inhibitor with antiplatelet and vasodilator properties. It has been recently verified that CLZ plays a significant role in the arteries by inhibiting the proliferation and growth of muscle cells, increasing the release of nitric oxide by the endotheliu...
Cilostazol/administración & dosificación,
Nanocápsulas/administración & dosificación,
Vasodilatadores/administración & dosificación,
Aterosclerosis/prevención & control,
Aorta Abdominal,
Inhibidores de Fosfodiesterasa 3/administración & dosificación,
Ratas Wistar,
Óxido Nítrico,
Glicoles de Propileno,
Inhibidores de Agregación Plaquetaria/administración & dosificación,
Modelos Animales de Enfermedad
Abstract In the current study, nanocapsules (NC) formulations containing a co-load of clotrimazole (C), a highly prescribed antifungal drug, and diphenyl diselenide [(PhSe)2], an organoselenium compound with a promising scope of pharmacological actions, were prepared. Formulations were characterized as w...
Abstract Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems and can ensure the desired pharmacological effect. In addition, it is manda...
Abstract Nanoparticles demonstrate an important role in the protection of bioactive compounds from external factors such as temperature, oxygen and light. In this study, poly-ε-caprolactone (PCL) nanoparticles entrapped β-carotene was produced using the nanoprecipitation method. Firstly, was ev...
André, Weibson Paz Pinheiro;
Paiva Junior, José Ribamar de;
Cavalcante, Géssica Soares;
Ribeiro, Wesley Lyeverton Correia;
Araújo Filho, José Vilemar de;
Santos, Jéssica Maria Leite dos;
Alves, Ana Paula Negreiros Nunes;
Monteiro, Jomar Patrício;
Morais, Selene Maia de;
Silva, Isaac Neto Goes da;
Oliveira, Lorena Mayana Beserra de;
Abreu, Flávia Oliveira Monteiro da Silva;
Bevilaqua, Claudia Maria Leal.
Abstract The objective of this study was to evaluate the efficacy of carvacryl acetate (CVA) and nanoencapsulated CVA (nCVA) on gastrointestinal nematodes of sheep. The CVA was nanoencapsulated with chitosan/gum arabic and the efficacy of nanoencapsulation (EE), yield, zeta potential, nanoparticle morpho...
Antihelmínticos/farmacología,
Antihelmínticos/toxicidad,
Tracto Gastrointestinal/parasitología,
Ratones,
Monoterpenos/farmacología,
Monoterpenos/toxicidad,
Nanocápsulas/administración & dosificación,
Nanocápsulas/toxicidad,
Haemonchus/efectos de los fármacos,
Haemonchus/aislamiento & purificación,
Infecciones por Nematodos/veterinaria,
Infecciones por Nematodos/tratamiento farmacológico,
Recuento de Huevos de Parásitos,
Pruebas de Sensibilidad Parasitaria,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Ratas Wistar/sangre,
Ovinos/parasitología,
Enfermedades de las Ovejas/tratamiento farmacológico,
Enfermedades de las Ovejas/parasitología,
Pruebas de Toxicidad,
Resistencia a Medicamentos/efectos de los fármacos,
Bencimidazoles/farmacología,
Levamisol/farmacología,
Antihelmínticos/uso terapéutico,
Nanocápsulas/uso terapéutico,
Monoterpenos/uso terapéutico,
Helmintiasis Animal/tratamiento farmacológico,
Hemoncosis/tratamiento farmacológico
