Abstract Nanoparticles are considered viable options in the treatment of cancer. This study was conducted to investigate the effect of magnetite nanoparticles (MNPs) and magnetite folate core shell (MFCS) on leukemic and hepatocarcinoma cell cultures as well as their effect on the animal model of acute m...
Enzymes immobilized onto substrates with excellent selectivity and activity show a high stability and can withstand extreme experimental conditions, and their performance has been shown to be retained after repeated uses. Applications of immobilized enzymes in various fields benefit from their unique cha...
BACKGROUND: Super-paramagnetic iron oxide nanoparticles (SPION) contain a chemotherapeutic drug and are regarded as a promising technique for improving targeted delivery into cancer cells. RESULTS: In this study, the fabrication of 5-fluorouracil (5-FU) was investigated with loaded Dextran (DEXSPION) usi...
Fluorouracilo/administración & dosificación,
Neoplasias Hepáticas/tratamiento farmacológico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Nanopartículas/administración & dosificación,
Expresión Génica/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Sistemas de Liberación de Medicamentos,
Polímeros,
Nanopartículas de Magnetita,
Preparaciones de Acción Retardada,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Citometría de Flujo
Moyamoya disease (MMD) is currently thought to involve endothelial progenitor cells (EPCs). We investigated whether superparamagnetic iron oxide (SPIO) can be used to label EPCs. Mononuclear cells from 10 moyamoya disease patients were isolated, and cluster of differentiation 133 (CD133) positive cells s...
Gold coated magnetite nanoparticles were prepared and coated with ranibizumab as an ocular drug delivery system. The surface morphologies of the nanoparticles were determined by Scanning Electron Microscopy (SEM). The size and surface charge were determined by using the dynamic light scattering (DLS) tec...
Técnicas In Vitro/instrumentación,
Nanopartículas de Magnetita/administración & dosificación,
Ranibizumab/efectos adversos,
Microscopía Electrónica de Rastreo/métodos,
Análisis Espectral/instrumentación,
Dispersión Dinámica de Luz/instrumentación,
Ensayo de Inmunoadsorción Enzimática/instrumentación,
Métodos,
Oro,
Rayos X,
Sistemas de Liberación de Medicamentos
Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was ...
ABSTRACT Objective: To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device. Methods: The magnetic nanoparticles coated with aminosilane were used for the therapy of magnetic hyperthermia, being evaluated the specific absorption rate of the magne...
Técnicas de Cultivo de Célula/métodos,
Línea Celular Tumoral,
Supervivencia Celular,
Fluorescencia,
Glioblastoma/terapia,
Hipertermia Inducida/métodos,
Dispositivos Laboratorio en un Chip,
Campos Magnéticos,
Nanopartículas de Magnetita/uso terapéutico,
Reproducibilidad de los Resultados,
Temperatura,
Factores de Tiempo,
Resultado del Tratamiento
ABSTRACT Objective: To evaluate the potential of magnetic hyperthermia using aminosilane-coated superparamagnetic iron oxide nanoparticles in glioblastoma tumor model. Methods: The aminosilane-coated superparamagnetic iron oxide nanoparticles were analyzed as to their stability in aqueous medium and th...
Análisis de Varianza,
Temperatura Corporal,
Neoplasias Encefálicas/terapia,
Línea Celular Tumoral,
Modelos Animales de Enfermedad,
Compuestos Férricos/química,
Compuestos Férricos/uso terapéutico,
Glioblastoma/terapia,
Hipertermia Inducida/métodos,
Mediciones Luminiscentes,
Magnetoterapia/métodos,
Nanopartículas de Magnetita/química,
Nanopartículas de Magnetita/uso terapéutico,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Nanopartículas (NPs) tem ganhado notoriedade crescente em aplicações biomédicas. Podendo ser constituídas de diversos materiais, NPs tem sido empregadas como agentes de contraste, na liberação direcionada e controlada de fármacos, em terapia para tratamento de câncer, em catálise heterogênea, ...
Abstract Purpose: To evaluate the effect of oxacillin bonded to magnetic nanoparticles in local infection model in rat. Methods: Twelve Wistar rats weighing 290±18g were randomly divided into four groups (n=6, each) and all rats had a magnet ring sutured on their right thighs. In the biodistribution g...
