LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Protective Autophagy in 5-Fluorouracil-Resistant Colorectal Cancer Cells and ERK-RSK-ABCG2 Linkage

Yoon, Sang-Pil.

Int. j. morphol; 41 (6), 2023

SUMMARY: To evaluate the anti-cancer effects of yeast extract on resistant cells, autophagy and necroptosis were investigated in 5-fluorouracil (5-FU)-resistant colorectal cancer cells. Further underlying characteristics on drug resistance were evaluated, focused on ERK-RSK-ABCG2 linkage. SNU-C5 and 5-FU...

Extractos Vegetales/farmacología, Neoplasias Colorrectales/tratamiento farmacológico, Resistencia a Antineoplásicos, Fluorouracilo, Autofagia, Antineoplásicos/farmacología, Proteínas Quinasas S6 Ribosómicas 90-kDa, Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2, Células Tumorales Cultivadas, Levaduras, Necroptosis, Supervivencia Celular/efectos de los fármacos, Western Blotting, Electroforesis

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The neuroprotection of cerebrolysin after spontaneous intracerebral hemorrhage through regulates necroptosis via Akt/ GSK3B signaling pathway

Tao, Yunna; Xu, Yeping; Shen, Meng; Feng, Xiaoyan; Wu, Yan; Wu, Youping; Shen, Liuyan; Wang, Yuhai.

Acta cir. bras; 36 (10), 2021

ABSTRACT Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability with a huge economic burden worldwide. Cerebrolysin (CBL) has been previously used as a nootropic drug. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death af...

Aminoácidos, Apoptosis, Hemorragia Cerebral/tratamiento farmacológico, Glucógeno Sintasa Quinasa 3 beta/farmacología, Ratones Endogámicos C57BL, Necroptosis, Neuronas/metabolismo, Neuroprotección, Fármacos Neuroprotectores/farmacología, Proteínas Proto-Oncogénicas c-akt/metabolismo, Transducción de Señal

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Controlled decompression alleviates early brain injury in rabbit intracranial hypertension model by regulating apoptosis/necroptosis

Zhang, Can; Wang, Yue; Chen, Junhui; Yang, Shuo; Wang, Yuhai.

Acta cir. bras; 36 (4), 2021

ABSTRACT Purpose To evaluate the effects of controlled decompression and rapid decompression, explore the potential mechanism, provide the theoretical basis for the clinical application, and explore the new cell death method in intracranial hypertension. Methods Acute intracranial hypertension was trig...

Apoptosis, Lesiones Encefálicas, Descompresión, Hipertensión Intracraneal, Necroptosis, Conejos, Ratas Sprague-Dawley

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Allium jesdianum Extract Induces Oxidative Stress and Necroptosis in Human Colorectal Cancer (HT-29) Cell Line

Alidadi, Hadis; Shirani, Maryam; Samimi, Azin; Salimi, Anayatollah; Ashtari, Atefeh; Khorsandi, Layasadat.

Braz. arch. biol. technol; 64 (), 2021

Abstract This study aimed to evaluate the toxic impact of hydro-alcoholic Allium jesdianum extract (AJE) on the growth of HT-29 human colorectal cancer cell line. Phytochemical analysis using gas chromatography and mass spectroscopy (GCMS) was done to determine the bioactive components of AJE. HT-29 cell...

Neoplasias Colorrectales, Allium/toxicidad, Necroptosis, Estrés Oxidativo

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