SUMMARY: Marein is a flavonoid compound that reduces blood glucose and lipids and has a protective effect in diabetes. However, the effect and mechanism(s) of marein on renal endothelial-mesenchymal transition in diabetic kidney disease (DKD) have not been elucidated. In this study, single-cell sequencin...
Bashir, Salah O;
Morsy, Mohamed D;
Mohammed, Muataz E;
Abbas, Amr M;
Badi, Rehab M;
Osman, Osama M;
Dawood, Amal F;
Saeed, Amal M;
Eid, Refaat A;
Sabir, Deema K.
SUMMARY: This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, and oxidative stress in a rat model of diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, norm...
Acacia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Nefropatías Diabéticas/tratamiento farmacológico,
ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos,
ATPasa Intercambiadora de Sodio-Potasio/genética,
Estrés Oxidativo,
Control Glucémico,
Insulina/administración & dosificación,
Quimioterapia Combinada,
Expresión Génica,
Malondialdehído,
Superóxido Dismutasa,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Riñón/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Hemoglobina Glucada/análisis,
d0123330
Existe un gran número de especies utilizadas tradicionalmente en Guatemala para el tratamiento de condiciones asociadas al
riñón, con una importante relación con el sistema de purificación de sangre, de excreción de sustancias y de protección renal. Sin embargo, hasta la fecha no ha sido explorad...
Nefropatías Diabéticas/inducido químicamente,
Deshidratación/inducido químicamente,
Tagetes/efectos de los fármacos,
Extractos Vegetales/uso terapéutico,
Sustancias Protectoras/uso terapéutico,
Nefropatías Diabéticas/tratamiento farmacológico,
Deshidratación/tratamiento farmacológico,
Gentamicinas/efectos adversos,
Tagetes/efectos adversos,
Urea/análisis,
Creatinina/sangre,
Glucosa/análisis,
Ratas Wistar,
Ratones,
Sustancias Protectoras/análisis
To explore a new underlying molecular mechanism of Huangkui Extract Powder (HKEP) in the alleviation of diabetic nephropathy (DN). Murine immortalized podocytes were divided into (i) normal glucose (NG, 5.6 mM), (ii) NG + HKEP (0.45 g/L), (iii) HG, and (iv) HG + HKEP (0.45 g/L) groups. MTT assay and fl...
Extractos Vegetales/administración & dosificación,
Nefropatías Diabéticas/tratamiento farmacológico,
Podocitos/efectos de los fármacos,
Polvos,
Técnicas de Cultivo de Célula,
Apoptosis/efectos de los fármacos,
Ciclo Celular,
Extractos Vegetales/genética,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Western Blotting,
Glucosa
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and β-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were consti...
Benzoquinonas/administración & dosificación,
Ácidos Aminoisobutíricos/administración & dosificación,
Nefropatías Diabéticas/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Estreptozocina,
Ratas Sprague-Dawley,
Inmunohistoquímica,
Estrés Oxidativo,
Riñón/efectos de los fármacos,
Peso Corporal,
Glucosa/análisis,
Glutatión/análisis,
Nitrógeno de la Urea Sanguínea,
Creatinina/análisis
ABSTRACT Objective: To investigate the efficacy and safety of febuxostat on renal function in CKD stage 3 diabetic nephropathy patients. Methods: Patients in our hospital with chronic kidney disease (CKD) stage 3 diabetic nephropathy (DN) complicated by high serum uric acid (360 µmol/L) were recruited...
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear...
Abstract Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus associated with significant morbidity and mortality regarded as a global health issue. MicroRNAs - small RNA molecules responsible for the post-transcriptional regulation of gene expression by degradation of messenger R...
Albuminuria,
Biomarcadores/sangre,
Biomarcadores/orina,
Diabetes Mellitus Tipo 1/complicaciones,
Diabetes Mellitus Tipo 2/complicaciones,
Nefropatías Diabéticas/diagnóstico,
Nefropatías Diabéticas/tratamiento farmacológico,
Nefropatías Diabéticas/genética,
Nefropatías Diabéticas/patología,
Tasa de Filtración Glomerular,
MicroARNs/sangre,
MicroARNs/orina,
Terapia Molecular Dirigida
Ren, Wei;
Zhao, Chen;
Wang, Yan;
Fang, Yuan;
Huang, Zhenzhen;
Chen, Wei;
Wang, Lihua;
Hu, Wen;
Wang, Ke;
Ni, Lijun.
Abstract Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN). Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), a...
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología,
Colágeno Tipo IV/efectos adversos,
Colágeno Tipo IV/metabolismo,
Nefropatías Diabéticas/tratamiento farmacológico,
Nefropatías Diabéticas/metabolismo,
Fibronectinas/efectos de los fármacos,
Fibronectinas/metabolismo,
Inmunohistoquímica,
Factor I del Crecimiento Similar a la Insulina/antagonistas & inhibidores,
Factor I del Crecimiento Similar a la Insulina/metabolismo,
Metaloproteinasas de la Matriz/efectos de los fármacos,
Metaloproteinasas de la Matriz/metabolismo,
Células Mesangiales/efectos de los fármacos,
Células Mesangiales/metabolismo,
Ramipril/farmacología,
Ratas Sprague-Dawley
Abstract Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constr...
