Results: 29

Expression and Clinical Significance of CLCA2 in Pan-Cancer

Int. j. morphol; 42 (2), 2024
SUMMARY: The calcium-activated chloride channel (CLCA2) performs a vital function in the intricate process of tumorigenesis. Using a bioinformatics analysis system, we conducted a pan-cancer investigation on CLCA2 to explore its association with tumor prognosis and its involvement in immunology. In order...

Avances y desafíos locales en el diagnóstico molecular de tumores sólidos: una mirada sanitaria hacia la oncología de precisión en Chile

Rev. méd. Chile; 151 (10), 2023
El cáncer seguirá siendo uno de los mayores desafíos para la salud pública a nivel local y mundial. Actualmente, en nuestro país, el cáncer es la principal causa de muerte. Gracias al enorme conocimiento acumulado en las últimas décadas sobre las bases celulares y moleculares del cáncer, se ha d...

Consenso para la consejería genética y diagnóstico molecular oncológicos: Declaración de Punta Arenas

Rev. méd. Chile; 151 (9), 2023

MicroRNAs: understanding their role in gene expression and cancer

ABSTRACT MicroRNAs are small RNA molecules that regulate gene expression in cells. These small molecules comprise 17 to 25 nucleotides and are able to recognize target messenger RNAs by sequence complementarity and regulate their protein translation. Different microRNAs are expressed in all human cells. ...

Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: a systematic review and meta-analysis

Background: TP73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding RNA (lncRNA), has been reported to be upregulated in various kinds of tumors, and shows a variable influence on living quality and prognosis of patients. Thus, we conducted a meta-analysis to evaluate the overall prognostic v...

A Utilização de Telemedicina para o Aconselhamento Genético em Oncologia

Rev. bras. cancerol; 66 (1), 2020
Introdução: O desenvolvimento da medicina com a descoberta do genoma humano revolucionou o conhecimento, o acompanhamento e o tratamento do câncer, proporcionando a utilização de novos métodos de diagnóstico e tratamento para diversos tipos de neoplasias e permitindo o aconselhamento genético. O ...

Rol del consumo de alcohol y antioxidantes sobre la metilación global del ADN y cáncer

Int. j. morphol; 36 (1), 2018
RESUMEN: El alcoholismo es una enfermedad crónica recidivante asociada a disfunción psicológica, social y física. El alcohol no sólo es una droga adictiva, también produce alteraciones en las actividades y funciones de múltiples sistemas y órganos. Actualmente, diversos estudios demuestran que el...

Pharmacogenetic testing in oncology: a Brazilian perspective

Clinics; 73 (supl.1), 2018
Pharmacogenetics, a major component of individualized or precision medicine, relies on human genetic diversity. The remarkable developments in sequencing technologies have revealed that the number of genetic variants modulating drug action is much higher than previously thought and that a true personaliz...