SUMMARY: The calcium-activated chloride channel (CLCA2) performs a vital function in the intricate process of tumorigenesis. Using a bioinformatics analysis system, we conducted a pan-cancer investigation on CLCA2 to explore its association with tumor prognosis and its involvement in immunology. In order...
For more than 20 years, immunohistochemistry has represented an auxiliary test of great relevance to support pathological work, however, it should be noted that the pillar of diagnosis continues and will continue to be the classic morphological description based o...
En esta revisión sistemática exploratoria, presentamos la evidencia registrada en la literatura, de que la microbiota oral puede generar una acción carcinogénica, actuando a través de tres mecanismos principales: sobre el medio extracelular, activando vías de señalización intracelular y/o generan...
The antiparasitic niclosamide has shown promising anticancer activity in preclinical studies against several types of cancer, such as colorectal and prostate. Thus, the objective of this work was to develop innovative formulations for the repositioning of niclosamide as an anticancer agent. In chapter I,...
ABSTRACT Introduction: Children and adolescents with cancer are particularly vulnerable to malnutrition and require special attention on nutritional assessment. An adequate nutritional status during treatment is essential in reducing morbidity and mortality, being a modifiable risk factor for clinical o...
Antineoplásicos/uso terapéutico,
Autofagia/fisiología,
Neoplasias/tratamiento farmacológico,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Serina-Treonina Quinasas TOR/metabolismo,
Antineoplásicos/economía,
Everolimus/economía,
Everolimus/uso terapéutico,
Neoplasias/metabolismo,
Sirolimus/análogos & derivados,
Sirolimus/economía,
Sirolimus/uso terapéutico
Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of ...
Enfermedades Óseas/metabolismo,
Enfermedades Óseas/fisiopatología,
Remodelación Ósea/fisiología,
Progresión de la Enfermedad,
Matriz Extracelular/fisiología,
Inhibidores de la Metaloproteinasa de la Matriz/uso terapéutico,
Metaloproteinasas de la Matriz/fisiología,
Neoplasias/metabolismo,
Neoplasias/fisiopatología,
Osteoblastos/fisiología,
Inhibidores Tisulares de Metaloproteinasas/fisiología,
Calcificación Vascular/metabolismo,
Calcificación Vascular/fisiopatología
Roco, Ángela;
Cerda, Berta;
Cayún, Juan Pablo;
Lavanderos, Alejandra;
Rubilar, Juan Carlos;
Cerro, Roberto;
Acevedo, Christian;
Cáceres, Dante;
Varela, Nelson;
Quiñones, Luis A.
El cáncer es la segunda causa de muerte en el mundo, según datos de la Organización Mundial de la Salud (OMS) en el año 2015 ocasionó 8,8 millones de muertes. Dentro de los factores de riesgo para el desarrollo de cáncer se encuentran el tabaquismo y el consumo de alcohol. En Chile el 33,6% de la p...
Consumo de Bebidas Alcohólicas/efectos adversos,
Predisposición Genética a la Enfermedad,
Inactivación Metabólica/genética,
Neoplasias/etiología,
Fumar Tabaco/efectos adversos,
Consumo de Bebidas Alcohólicas/genética,
Consumo de Bebidas Alcohólicas/metabolismo,
Marcadores Genéticos,
Neoplasias/metabolismo,
Farmacogenética,
Polimorfismo Genético,
Factores de Riesgo,
Fumar Tabaco/genética,
Fumar Tabaco/metabolismo
One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on meta...
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiothe...
