MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer
Braz. j. med. biol. res; 50 (6), 2017
Colorectal cancer (CRC) is the fourth leading cause of cancer-induced mortality. Histone deacetylase 2 (HDAC2) is involved in prognosis and therapy of CRC. This study aimed to explore novel therapeutic targets for CRC. The alteration of HDAC2 expression in CRC tissues was estimated by qRT-PCR. After lent...
Apoptosis, Proliferación Celular/efectos de los fármacos, Supervivencia Celular, Neoplasias Colorrectales/enzimología, Neoplasias Colorrectales/genética, Regulación hacia Abajo, Células HCT116, Histona Desacetilasa 2/genética, Histona Desacetilasa 2/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Transfección, Regulación hacia Arriba