Dietary consumption of polyphenols, found in fruits and vegetables, has been associated with a potentially protective role in colorectal cancer (CRC). To establish the state of knowledge regarding advances in polyphenols, CCR and action mechanisms a systematic review and an analysis of infor...
Cancer cells
modify lipid metabolism to proliferate,
Passiflora edulis
(
P. edulis
) fruit juice
(ZuFru) has antitumor activity, but whether a mechanism is through modulation of cell lipids is unknown.
T
o establish if ZuFru modifies cholesterol and triglycerides in SW480
and SW620...
Passiflora/química,
Extractos Vegetales/administración & dosificación,
Anticarcinógenos,
Jugos de Frutas y Vegetales/análisis,
Neoplasias Colorrectales/tratamiento farmacológico,
Proliferación Celular/efectos de los fármacos,
Colesterol,
Triglicéridos,
Línea Celular Tumoral/efectos de los fármacos,
Extractos Vegetales/química,
Fenoles/análisis,
Flavonoides/análisis,
Antioxidantes,
Supervivencia Celular/efectos de los fármacos,
Polisacáridos/análisis
Introduction: Chemotherapy response in early age-onset colorectal cancer patients is still controversial, and the results of chemotherapy response are unknown. Therefore, the purpose of this study is to determine the relationship between the age of colorectal cancer patients and histopathological feature...
SUMMARY: To evaluate the anti-cancer effects of yeast extract on resistant cells, autophagy and necroptosis were investigated in 5-fluorouracil (5-FU)-resistant colorectal cancer cells. Further underlying characteristics on drug resistance were evaluated, focused on ERK-RSK-ABCG2 linkage. SNU-C5 and 5-FU...
Extractos Vegetales/farmacología,
Neoplasias Colorrectales/tratamiento farmacológico,
Resistencia a Antineoplásicos,
Fluorouracilo,
Autofagia,
Antineoplásicos/farmacología,
Proteínas Quinasas S6 Ribosómicas 90-kDa,
Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2,
Células Tumorales Cultivadas,
Levaduras,
Necroptosis,
Supervivencia Celular/efectos de los fármacos,
Western Blotting,
Electroforesis
Pavón, Alequis;
Corsini, Gino;
Orellana, Paz;
Calisto, Nancy;
Navarro, Laura;
Wiese, Guillermo;
Cortés-Cortés, Piedad;
Gidekel, Manuel;
Gutierrez-Moraga, Ana;
Salazar, Lorena.
SUMMARY: Cancer is the second leading cause of death in the world and colorectal cancer is the only cancer that has shown a sustained increase in mortality in the last decade. In the search for new chemotherapeutic agents against cancer, extremophilic microorganisms have shown to be a potential source to...
Microbiología del Suelo,
Regiones Antárticas,
Bacillus/fisiología,
Bacillus/aislamiento & purificación,
Bacillus/genética,
Proliferación Celular/efectos de los fármacos,
Neoplasias Colorrectales/tratamiento farmacológico,
Línea Celular Tumoral/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
ARN Ribosómico 16S,
Fenotipo,
Genotipo,
Técnicas In Vitro,
Adenocarcinoma/tratamiento farmacológico,
Reacción en Cadena de la Polimerasa
Abstract Colorectal cancer (CRC) is one of the most common cancers leading to comorbidities and mortalities globally. The rational of current study was to evaluate the combined epigallocatechin gallate and quercetin as a potent antitumor agent as commentary agent for therapeutic protocol. The present stu...
O câncer colorretal é uma neoplasia com alta prevalência e letalidade. A razão desse elevado número de mortes é a detecção da doença em estágios metastáticos, de difícil cura e que necessitam de terapia quimioterápica adjuvante ou paliativa. Na atualidade, o principal tratamento quimioteráp...
Colorectal cancer is the 4thcause of cancer death; with considering the growth process of this cancer and the necessity of early diagnosis, the purpose of the research is to state the LncRNA 00970, LncRNA UCAI,and the Wntgene before and after the treatment by 5-Azacytidine epigenetic medi...
Técnicas In Vitro/métodos,
Azacitidina/análisis,
Biomarcadores,
ADN/análisis,
Diagnóstico Precoz,
Neoplasias Colorrectales/tratamiento farmacológico,
ARN Largo no Codificante/efectos de los fármacos,
Genes,
Epigenómica,
Línea Celular/efectos de los fármacos,
Neoplasias del Colon/diagnóstico,
Azacitidina/antagonistas & inhibidores,
Neoplasias Colorrectales/mortalidad,
Neoplasias Colorrectales/terapia,
ARN Largo no Codificante,
Neoplasias del Colon/tratamiento farmacológico,
Neoplasias del Colon/terapia
Abstract To evaluate possible new drugs for the treatment of Colorectal Carcinoma (CRC) using in silico tools was the main objective of this study. The method of analysis used was the in silico evaluation of tumor markers and their interaction with selected drugs, through the study of its pharmacokinetic...
