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Effect of Survivin Down-Regulation by Egr1-Survivin shRNA Combined with Radiotherapy on Radiosensitivity of Esophageal Squamous Carcinoma

Lv, Yin; Zhang, Jinrong; Lu, Yanrong; Zhang, Xin; Wang, Haifeng.
Int. j. morphol; 41 (6), 2023
SUMMARY: This study is to investigate the effect of survivin down-regulation by Egr1-survivin shRNA combined with radiotherapy on the apoptosis and radiosensitivity of esophageal squamous cell carcinoma ECA109 and KYSE150 cells. ECA109 and KYSE150 cells were transfected with Egr1-survivin shRNA, and then...
Neoplasias Esofágicas/terapia, Carcinoma de Células Escamosas de Esófago/terapia, Neoplasias Esofágicas/genética, Carcinoma de Células Escamosas de Esófago/genética, Transfección, Survivin, Fármacos Sensibilizantes a Radiaciones, Neoplasias Esofágicas/radioterapia, Carcinoma de Células Escamosas de Esófago/radioterapia, Línea Celular Tumoral/efectos de la radiación, ARN Mensajero, Western Blotting, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Abajo, Apoptosis, Citometría de Flujo, Caspasa 3, Caspasa 9, ARN Interferente Pequeño, Terapia Combinada, Tolerancia a Radiación, Proteína 1 de la Respuesta de Crecimiento Precoz
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Human esophageal fibroblast-derived exosomal miR-21 reduced the cisplatin sensitivity to esophageal carcinoma EC9706 cells

Wan, Jiajin; Niu, Chunling; Wang, Baiyan; Han, Qianqian; Chen, Yulon; Feng, Shuying; Yang, Lianhe.
Braz. j. med. biol. res; 54 (10), 2021
The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or miR-21 mimics transfected-HEF in the tran...
Apoptosis, Proteínas Reguladoras de la Apoptosis/metabolismo, Carcinoma, Línea Celular Tumoral, Proliferación Celular, Cisplatino/farmacología, Neoplasias Esofágicas/tratamiento farmacológico, Neoplasias Esofágicas/genética, Fibroblastos/metabolismo, MicroARNs/genética, Proteínas de Unión al ARN, Microambiente Tumoral
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MET overexpression and intratumor heterogeneity in esophageal squamous cell carcinoma

Abboud, H S; Camuzi, D; Rapozo, D C; Fernandes, P V; Nicolau-Neto, P; Guaraldi, S; Simão, T A; Ribeiro Pinto, L F; Gonzaga, I M; Soares-Lima, S C.
Braz. j. med. biol. res; 54 (8), 2021
Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic a...
Brasil, Carcinoma de Células Escamosas/genética, Línea Celular Tumoral, Neoplasias Esofágicas/genética, Carcinoma de Células Escamosas de Esófago/genética, Regulación Neoplásica de la Expresión Génica, Neoplasias de Cabeza y Cuello, Proteínas Proto-Oncogénicas c-met/genética, Proteínas Proto-Oncogénicas c-met/metabolismo
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Long non-coding RNA KCNQ1 overlapping transcript 1 promotes the progression of esophageal squamous cell carcinoma by adsorbing microRNA-133b

Xu, Haitao; Miao, Jing; Liu, Shuai; Liu, Hongjian; Zhang, Lianguo; Zhang, Qingguang.
Clinics; 76 (), 2021
OBJECTIVE: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: KCNQ1OT1 expression was detected in ESCC tissues ...
Proliferación Celular/genética, Neoplasias Esofágicas/genética, Carcinoma de Células Escamosas de Esófago/genética, Canal de Potasio KCNQ1/genética, MicroARNs/genética, Fosfatidilinositol 3-Quinasas, ARN Largo no Codificante/genética
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Regulação da expressão das DNA metiltransferases pelas proteínas p53 e Sp1 em carcinoma epidermóide de esôfago

Sousa, Vanessa Paiva Leite de.
O câncer de esôfago (CE) é um tumor altamente frequente e letal, correspondendo ao oitavo lugar em incidência e sexto em letalidade, dentro todos os tipos de tumores. O subtipo histopatológico mais frequente de CE é o carcinoma epidermóide de esôfago (CEE) que corresponde a aproximadamente 80% do...
Neoplasias Esofágicas/genética, Carcinoma de Células Escamosas/genética, Genes p53, Factor de Transcripción Sp1
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