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In vivo induction of hepatocellular carcinoma by diethylnitrosoamine and pharmacological intervention in Balb C mice using Bergenia ciliata extracts

Dar, K K; Ali, S; Ejaz, M; Nasreen, S; Ashraf, N; Gillani, S F; Shafi, N; Safeer, S; Khan, M A; Andleeb, S; Mughal, T A.
Braz. j. biol; 79 (4), 2019
Abstract Background Hepatocellular carcinoma is the most frequent primary malignancy of liver and accounts for as many as one million deaths worldwide in a year. Objectives The aim of the present study was to evaluate the anti-cancerous efficiency of Bergenia ciliata rhizome against diethylnitrosoami...
Carcinoma Hepatocelular/patología, Carcinoma Hepatocelular/inducido químicamente, Alquilantes/farmacología, Dietilnitrosamina/farmacología, Neoplasias Hepáticas/inducido químicamente, Neoplasias Hepáticas/patología, Ratones Endogámicos BALB C, Neoplasias Experimentales/inducido químicamente, Extractos Vegetales/farmacología, Saxifragaceae
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Expression of Ki-67 and P16 INK4a in chemically-induced perioral squamous cell carcinomas in mice

Alves, Ângela Valéria Farias; Ribeiro, Danielle Rodrigues; Lima, Sonia Oliveira; Reis, Francisco Prado; Soares, Andréa Ferreira; Gomes, Margarete Zanardo; Albuquerque Júnior, Ricardo Luiz Cavalcanti de.
Rev. Col. Bras. Cir; 43 (2), 2016
ABSTRACT Objective: to evaluate the influence of Ki-67 and P16INK4a proteins immunohistochemical expressions on the clinical and morphological parameters of perioral squamous cell carcinoma induced with 9,10-dimethyl-1,2-benzanthracene (DMBA) in mice. Methods: we topically induced the lesions in the or...
Carcinoma de Células Escamosas/inducido químicamente, Carcinoma de Células Escamosas/metabolismo, Inhibidor p16 de la Quinasa Dependiente de Ciclina/biosíntesis, Antígeno Ki-67/biosíntesis, Ratones, Neoplasias de la Boca/inducido químicamente, Neoplasias de la Boca/metabolismo, Neoplasias Experimentales/inducido químicamente, Neoplasias Experimentales/metabolismo
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