SUMMARY: Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote tumor cell proliferation, migration, and invasion. However, the role of MALAT1 in gastric cancer (GC) is still unclear. We aimed to investigate the corre...
Neoplasias Gástricas/patología,
ARN Largo no Codificante,
Proliferación Celular,
Factor A de Crecimiento Endotelial Vascular,
Serina-Treonina Quinasas TOR,
Transducción de Señal,
Neoplasias Gástricas/genética,
ARN/genética,
Western Blotting,
Genes Reporteros,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación Neoplásica de la Expresión Génica,
Movimiento Celular,
Apoptosis
Siendo el cáncer gástrico la 3ª causa de muerte por cáncer en Chile, y existiendo estrategias de tamizaje consistentes en pesquisa de lesiones preneoplásicas de la mucosa gástrica, es relevante conocer los aspectos genéticos y moleculares que puedan ser aplicados, en la optimización de dichas est...
Neoplasias Gástricas/patología,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/metabolismo,
Lesiones Precancerosas/patología,
Lesiones Precancerosas/genética,
Lesiones Precancerosas/metabolismo,
Mucosa Gástrica/patología,
Mucosa Gástrica/metabolismo,
Inmunohistoquímica,
Biomarcadores de Tumor,
Tamizaje Masivo,
Genes p53,
Factor de Transcripción CDX2,
Mucina 2,
Factores de Riesgo,
Metaplasia
OBJECTIVES: Extracellular vesicle microRNAs (EV-miRNAs) have been demonstrated to be reliable candidate biomarkers for clinical applications. However, the clinical application potential of serum EV-miR-215-5p for gastric cancer (GC) remains poorly understood. The goal of our study was to determine the ef...
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric disease and cancer. We investigated the gene and prot...
Long non-coding RNA (lncRNA) is an essential regulator of carcinogenesis and cancer progression. In the study, we explored the role of lncRNA DLGAP1-AS1 in gastric cancer (GC). qRT-PCR was carried out to detect DLGAP1-AS1 expression in GC tissues and cell lines. CCK-8 assay, EdU assay, and transwell expe...
OBJECTIVES: Extracellular vesicle microRNAs (EV-miRNAs) have been demonstrated to be reliable candidate biomarkers for clinical applications. However, the clinical application potential of serum EV-miR-215-5p for gastric cancer (GC) remains poorly understood. The goal of our study was to determine the ef...
Gonzalez Hormazabal, Patricio;
Pelaez, Diana;
Musleh, Maher;
Bustamante, Marco;
Stambuk, Juan;
Pisano, Raul;
Valladares, Hector;
Lanzarini, Enrique;
Chiong, Hector;
Suazo, Jose;
Quiñones, Luis A;
Varela, Nelson M;
Castro, V. Gonzalo;
Jara, Lilian;
Berger, Zoltan.
BACKGROUND: Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TL...
ABSTRACT BACKGROUND: The role of -251A>T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE: Therefore, we performed a meta-analysis to provide a comprehensive data on t...
This study was designed to investigate the expression of RBM8A protein in patients with gastric cancer (GC) and to explore its correlation with clinical pathological features as well as prognosis. One hundred pairs of gastric carcinoma tissues and adjacent tissues from patients undergoing gastrectomy for...
Biomarcadores de Tumor/genética,
Mucosa Gástrica/patología,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Metástasis Linfática/patología,
Metástasis de la Neoplasia,
Estadificación de Neoplasias,
Pronóstico,
Proteínas Proto-Oncogénicas/metabolismo,
ARN Mensajero/metabolismo,
Proteínas de Unión al ARN/genética,
Proteínas de Unión al ARN/metabolismo,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Análisis de Supervivencia
BACKGROUND: Previous studies have shown that long noncoding RNA (IncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this IncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC0048...
MicroARNs/metabolismo,
Proteína Quinasa 1 Activada por Mitógenos/metabolismo,
ARN Largo no Codificante/metabolismo,
Neoplasias Gástricas/metabolismo,
Carcinogénesis/metabolismo,
Línea Celular Tumoral/metabolismo,
Células Epiteliales/metabolismo,
Luciferasas/metabolismo,
MicroARNs/genética,
ARN Largo no Codificante/genética,
Neoplasias Gástricas/genética,
Apoptosis,
Movimiento Celular,
Supervivencia Celular,
Regulación Neoplásica de la Expresión Génica,
Ratones Endogámicos BALB C,
Ensayos Antitumor por Modelo de Xenoinjerto
