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Evaluating mmp-2 and tgfß-ri expression in circulating tumor cells of pancreatic cancer patients and their correlation with clinical evolution

Gasparini-Junior, José Luiz; Fanelli, Marcello Ferretti; Abdallah, Emne Ali; Chinen, Ludmilla Thomé Domingos.
ABCD (São Paulo, Impr.); 32 (2), 2019
ABSTRACT Background: Metastasis is common in the diagnosis of pancreatic cancer, and the presence of epithelial-mesenchymal transition markers in circulating tumor cells may suggest worse prognosis. Aim: To correlate the number of circulating tumor cells (CTCs) in the peripheral blood of patients with...
Adenocarcinoma/sangre, Adenocarcinoma/patología, Biomarcadores de Tumor/sangre, Progresión de la Enfermedad, Transición Epitelial-Mesenquimal, Estimación de Kaplan-Meier, Metaloproteinasa 2 de la Matriz/sangre, Clasificación del Tumor, Estadificación de Neoplasias, Células Neoplásicas Circulantes/química, Células Neoplásicas Circulantes/patología, Neoplasias Pancreáticas/sangre, Neoplasias Pancreáticas/patología, Estudios Prospectivos, Receptor Tipo I de Factor de Crecimiento Transformador beta/sangre, Valores de Referencia, Factores de Tiempo, Carga Tumoral, Vimentina/sangre
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The role of immunoinflammatory markers in the prognosis and resectability of pancreatic adenocarcinoma

Eyff, Tatiana Falcão; Bosi, Henrique Rasia; Toni, Mariana Sandrin; Zilio, Mariana Blanck; Corso, Carlos Otavio; Bersch, Vivian Pierri; Osvaldt, Alessandro Bersch.
ABCD (São Paulo, Impr.); 31 (2), 2018
ABSTRACT Background: Pancreatic adenocarcinoma has a high mortality rate. A prognostic tool is essential for a better risk stratification. The neutrophil/lymphocyte ratio and adaptations and the platelet/lymphocyte ratio seem promising for this purpose. Aim: Evaluate the prognostic value of neutrophil/...
Adenocarcinoma/sangre, Adenocarcinoma/inmunología, Adenocarcinoma/mortalidad, Inflamación/sangre, Recuento de Leucocitos, Recuento de Linfocitos, Neutrófilos, Neoplasias Pancreáticas/sangre, Neoplasias Pancreáticas/inmunología, Neoplasias Pancreáticas/mortalidad, Recuento de Plaquetas, Pronóstico, Análisis de Supervivencia
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Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma

Zhao, J; Liang, Y; Yin, Q; Liu, S; Wang, Q; Tang, Y; Cao, C.
Braz. j. med. biol. res; 49 (8), 2016
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report p...
Biomarcadores de Tumor/sangre, Carcinoma Ductal Pancreático/sangre, Carcinoma Ductal Pancreático/diagnóstico, Estimación de Kaplan-Meier, Neoplasias Pancreáticas/sangre, Neoplasias Pancreáticas/diagnóstico, Neoplasias Pancreáticas/secundario, Pronóstico, Estudios Retrospectivos, Sensibilidad y Especificidad, Factor de Crecimiento Transformador beta1/sangre
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