Comment on "Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer"
Rev. Assoc. Med. Bras. (1992, Impr.); 67 (10), 2021
Results: 28
Prognostic and clinicopathological value of zwint expression levels in patients with lung adenocarcinoma: a systematic review and meta-analysis
Clinics; 76 (), 2021
The current study found that high Zeste White 10 interactor (ZWINT) expression is related to the poor prognosis of patients with a variety of cancers. This study mainly explored the relationship between the expression level of ZWINT and the prognosis of patients with lung adenocarcinoma (LUAD). Briefly, ...
Which Tyrosine Kinase Inhibitor Must We Apply Before? A Case Report of Crizotinib-resistant Patient with Concomitant EGFR and EML4-ALK Gene Mutations
West Indian med. j; 69 (3), 2021
ABSTRACT The concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocations in lung adenocancers are very rare scenarios. Until now, 42 cases described in the literature have all been treated by different drugs. There is no overall consensus regarding the...
Adenocarcinoma/genética, Neoplasias Pulmonares/genética, Mutación/genética, Genes erbB-1/genética, Exones/genética, Crizotinib/uso terapéutico, Inhibidores de Proteínas Quinasas/uso terapéutico, Docetaxel/uso terapéutico, Cisplatino/uso terapéutico, Antineoplásicos/uso terapéutico, Neoplasias Pulmonares/tratamiento farmacológico, Adenocarcinoma/tratamiento farmacológico
Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway
Braz. j. med. biol. res; 54 (2), 2021
The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells. This study also explored the potential anti-cancer mechanism of melittin in NSCLC cells. The results demonstrated that melittin suppre...
Apoptosis, Factor Apoptótico 1 Activador de Proteasas, Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Caspasa 3, Línea Celular Tumoral, Movimiento Celular, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Sistema de Señalización de MAP Quinasas, Meliteno/farmacología, Invasividad Neoplásica, Factor de Crecimiento Transformador beta/metabolismo
miR-183 promotes radioresistance of lung adenocarcinoma H1299 cells via epithelial-mesenchymal transition
Braz. j. med. biol. res; 54 (5), 2021
Lung adenocarcinomas are usually sensitive to radiation therapy, but some develop resistance. Radiation resistance can lead to poor patient prognosis. Studies have shown that lung adenocarcinoma cells (H1299 cells) can develop radioresistance through epithelial-mesenchymal transition (EMT), and this proc...
Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study
Clinics; 76 (), 2021
OBJECTIVES: Lung cancer is the leading cause of cancer-related deaths worldwide. However, factors associated with the survival of patients with advanced non-small-cell lung cancer (NSCLC) who received only hospice care are largely unclear. In this study, we aimed to determine the prognostic factors corre...
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Carcinoma de Pulmón de Células no Pequeñas/patología, Receptores ErbB/genética, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/patología, Mutación, Estadificación de Neoplasias, Pronóstico, Inhibidores de Proteínas Quinasas/uso terapéutico, Estudios Retrospectivos
Biomarker testing for advanced lung cancer by next-generation sequencing; a valid method to achieve a comprehensive glimpse at mutational landscape
Appl. cancer res; 40 (), 2020
Background: Next-generation sequencing (NGS) based assay for finding an actionable driver in non-small-cell lung cancer is a less used modality in clinical practice. With a long list of actionable targets, limited tissue, arduous single-gene assays, the alternative of NGS for broad testing in one experim...
Real-world molecular testing and treatment patterns in brazilian patients with newly diagnosed locally advanced or metastatic NSCLC
Clinics; 75 (), 2020
OBJECTIVES: To evaluate the molecular testing and treatment patterns in a retrospective cohort of newly diagnosed treatment-naïve patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC). METHODS: This is an observational retrospective cohort study conducted across 10 cancer cent...
Brasil, Carcinoma de Pulmón de Células no Pequeñas/diagnóstico, Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/genética, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/genética, Técnicas de Diagnóstico Molecular, Mutación, Inhibidores de Proteínas Quinasas, Estudios Retrospectivos
Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer
Rev Assoc Med Bras (1992); 66 (7), 2020
SUMMARY OBJECTIVE Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) has been reported to be involved in cancer progression. However, the clinical significance of NBAT1 in non-small cell lung cancer (NSCLC) is still unclear. Our present research aimed to explore whether NBAT1 serves as a ...
LINC00355 promoted the progression of lung squamous cell carcinoma through regulating the miR-466/LYAR axis
Braz. j. med. biol. res; 53 (12), 2020
LINC00355 has been reported aberrantly over-expressed and associated with poor prognosis in various types of cancer. However, reports regarding the effect of LINC00355 on lung squamous cell carcinoma (SCC) are rare. This study aimed to explore the function of LINC00355 in the development and progression ...