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Alpha-hederin induces the apoptosis of oral cancer SCC-25 cells by regulating PI3K/Akt/mTOR signaling pathway

Wang, Heyuan; Wu, Bing; Wang, Haotian.
Electron. j. biotechnol; 38 (), 2019
BACKGROUND: Oral cancer is one of the common malignant tumors of the head and neck. However, current treatments have numerous side effects, and drugs from natural sources may have better therapeutic potential. This research investigated the induction of apoptosis by α-hederin (α-HN), a constituent of P...
Ácido Oleanólico/análogos & derivados, Ácido Oleanólico/metabolismo, Saponinas/metabolismo, Neoplasias de la Boca/metabolismo, Caspasas, Citometría de Flujo, Proliferación Celular/efectos de los fármacos, Neoplasias de Cabeza y Cuello/metabolismo, Serina-Treonina Quinasas TOR/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, Proteínas Proto-Oncogénicas c-akt/metabolismo, Transducción de Señal/efectos de los fármacos, Pulsatilla, Ácido Oleanólico/farmacología, Saponinas/farmacología, Apoptosis/efectos de los fármacos, Supervivencia Celular, Western Blotting
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Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects

Andrade Filho, Pedro de Alcântara de; Rapoport, Abräo; Alves, Venâncio Avancini Ferreira; Denardin, Odilon Victor Porto; Andrade Sobrinho, Josias de; Carvalho, Marcos Brasilino de.
Säo Paulo med. j; 119 (3), 2001
CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal ...
Paraganglioma/patología, Neoplasias de Cabeza y Cuello/patología, Proteínas de Neoplasias/análisis, Biomarcadores de Tumor/química, Inmunohistoquímica, Estudios Retrospectivos, Cromograninas/análisis, Tumores Neuroendocrinos/patología, Tumores Neuroendocrinos/metabolismo, Paraganglioma/metabolismo, Neoplasias de Cabeza y Cuello/metabolismo
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