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Polymorphisms of matrix metalloproteinase-7 and -9 are associated with oral tongue squamous cell carcinoma

Nascimento, George João Ferreira do; Silva, Leorik Pereira da; Matos, Felipe Rodrigues de; Silva, Thayse Azevedo da; Medeiros, Silvia Regina Batistuzzo de; Souza, Lélia Batista de; Freitas, Roseana de Almeida.
Braz. oral res. (Online); 35 (), 2021
Abstract Matrix degradation is an important event in the progression, invasion and metastasis of malignant head and neck lesions. Imbalances, mutations and polymorphisms of MMPs and their inhibitors are observed in several cancer subtypes. The aim of this study was to evaluate the association of the MMP-...
Carcinoma de Células Escamosas/genética, Estudios de Casos y Controles, Predisposición Genética a la Enfermedad, Genotipo, Metaloproteinasa 7 de la Matriz/genética, Metaloproteinasa 9 de la Matriz/genética, Polimorfismo de Nucleótido Simple, Neoplasias de la Lengua/genética
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Hsa_circ_0002162 has a critical role in malignant progression of tongue squamous cell carcinoma through targeting miR-33a-5p

Zhang, Chunguang; Yao, Yuan; Bi, Lei.
Braz. j. med. biol. res; 54 (5), 2021
The aim of this study was to explore the effect of hsa_circ_0002162 on regulating cell proliferation, apoptosis, and invasion, and investigate its potential target microRNA (miRNA) in tongue squamous cell carcinoma (TSCC). Hsa_circ_0002162 expression was detected in human TSCC cell lines and human oral k...
Carcinoma de Células Escamosas/genética, Línea Celular Tumoral, MicroARNs/genética, ARN Circular, Lengua, Neoplasias de la Lengua/genética
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