Single nucleotide polymorphisms (SNPs) have important application value in the research of population genetics, hereditary diseases, tumors, and drug development. Conventional methods for detecting SNPs are typically based on PCR or DNA sequencing, which is time-consuming, costly, and requires complex in...
Altered expression of miR-182 has been observed in various types of human cancer. The purpose of this study was to investigate the expression of miR-182 and its role in prostate cancer (PCa). Expression of miR-182 and ST6GALNAC5 in tumor tissues and the Du145 PCa cell line was analyzed. Cell proliferatio...
ABSTRACT Objective To evaluate the effects of Arf6 downregulation on human prostate cancer cells. Materials and Methods The effects of Arf6 downregulation on cell proliferation, migration, invasion and apoptosis were assessed by MTT, BrdU, scratch, Transwell assays and flow cytometry respectively. AK...
ABSTRACT Purpose The microRNAs expression has emerged as a potential biomarker for the diagnosis and prognosis of prostate cancer. This study investigated the expression of miRNA-182 and miRNA-187 in prostate cancer patients and established a correlation between miRNA expression and staging of prostate...
ABSTRACT Objective This study aims to investigate the association of filamin A with the function and morphology of prostate cancer (PCa) cells, and explore the role of filamin A in the development of PCa, in order to analyze its significance in the evolvement of PCa. Materials and Methods A stably tr...
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular,
Células Cultivadas,
Colorimetría/métodos,
Filaminas/análisis,
Filaminas/genética,
Filaminas/fisiología,
Formazáns,
Plásmidos,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/patología,
Sales de Tetrazolio,
Factores de Tiempo,
Transfección/métodos,
Cicatrización de Heridas/fisiología
Background: PTEN loss is observed in 20–30% of prostate cancers and is associated with a poor outcome, but
clinical details of the impact of this biomarker are unclear for intermediate grade tumors. Methods: We investigated 43 radical prostatectomy-derived grade 7 prostate tumors from the Clinics Hospi...
Clasificación del Tumor,
Neoplasias de la Próstata/patología,
Heterogeneidad Genética,
Hibridación Fluorescente in Situ,
Inmunohistoquímica,
Fosfohidrolasa PTEN/metabolismo,
Prostatectomía,
Neoplasias de la Próstata/genética,
Biomarcadores de Tumor,
Pronóstico,
Estudios de Cohortes
Background: Epidermal growth factor receptor (EGFR) is potential prognostic biomarker expressed in many human cancers. Prognostic significance of EGFR immunohistochemical expression has not been established in prostatic acinar adenocarcinoma, therefore we aimed to evaluate the frequency of expression of ...
Receptores ErbB/análisis,
Carcinoma de Células Acinares/patología,
Neoplasias de la Próstata/patología,
Pronóstico,
Clasificación del Tumor,
Carcinoma de Células Acinares/diagnóstico,
Neoplasias de la Próstata/diagnóstico,
Carcinoma de Células Acinares/genética,
Neoplasias de la Próstata/genética,
Biomarcadores de Tumor,
Supervivencia sin Enfermedad
ABSTRACT Background: The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported. Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese...
Antígenos de Neoplasias/genética,
Pueblo Asiatico/genética,
Estudios de Casos y Controles,
China,
Expresión Génica,
Estudios de Asociación Genética,
Genotipo,
Modelos Logísticos,
Clasificación del Tumor,
Estadificación de Neoplasias,
Polimorfismo de Nucleótido Simple/genética,
Neoplasias de la Próstata/etnología,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/patología,
Medición de Riesgo/métodos,
Factores de Riesgo,
Fumar/efectos adversos
Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been te...
Adenoviridae/genética,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Genes Transgénicos Suicidas,
Terapia Genética/métodos,
Vectores Genéticos/uso terapéutico,
Neoplasias Pulmonares/genética,
Proteínas de Neoplasias/genética,
Antígeno Prostático Específico/genética,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/inmunología,
Neoplasias de la Próstata/terapia,
Proteína p53 Supresora de Tumor/biosíntesis
ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and metho...
Regiones no Traducidas/genética,
Proteínas de Ciclo Celular/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica/genética,
MicroARNs/antagonistas & inhibidores,
MicroARNs/fisiología,
Invasividad Neoplásica,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/mortalidad,
Neoplasias de la Próstata/patología,
Proteínas de Unión al ARN/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteínas Supresoras de Tumor/metabolismo,
Regulación hacia Arriba
