O Co-transportador Sódio-Iodo (NIS) é a porta de entrada para a avaliação de metástases e tratamento adjuvante do carcinoma diferenciado de tireoide (CDT). Apesar de uma apresentação mais agressiva comparada a adultos, por sua raridade, poucos estudos avaliaram as alterações moleculares do CDT p...
ABSTRACT Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age <...
ABSTRACT Objective: Although the prognostic role of BRAFV600E mutation in papillary thyroid carcinoma (PTC) is controversial, the American Thyroid Association (ATA) includes the mutational status in their risk stratification system. To evaluate the impact of the BRAFV600E mutation status on PTC risk str...
Coelho, Bárbara Parente;
Valentim, Flávia de Oliveira;
Miot, Hélio Amante;
Jaune, Danilo Takeshi Abe;
Hayashi, Caroline Yuki;
Oliveira, Cristiano Claudino de;
Marques, Mariângela de Alencar;
Tagliarini, José Vicente;
Castilho, Emanuel Celice;
Soares, Paula;
Mazeto, Gláucia Maria Ferreira da Silva.
ABSTRACT Objective: Follicular lesions of the thyroid with papillary carcinoma nuclear characteristics are classified as infiltrative follicular variant of papillary thyroid carcinoma-FVPTC (IFVPTC), encapsulated/well demarcated FVPTC with tumour capsular invasion (IEFVPTC), and the newly described cate...
SUMMARY The EIF1AX gene mutations have been recently associated with papillary thyroid carcinoma and anaplastic thyroid cancer. According with these reports, the gene as been considered as a drive gene for thyroid cancer development. However, the occurrence of these alterations in benign thyroid lesions ...
Introducción: El gen FOXE1 (Forkhead box E1) codifica para un factor de transcripción involucrado en la morfogénesis tiroidea. El cáncer papilar de tiroides (CPT) se ha asociado con polimorfismos (SNP) de FOXE1 rs1867277 y rs965513 en población asiática y europea. Nuestro objetivo fue investigar la...
Cáncer Papilar Tiroideo/genética,
Cáncer Papilar Tiroideo/epidemiología,
Neoplasias de la Tiroides/genética,
Neoplasias de la Tiroides/epidemiología,
Polimorfismo de Nucleótido Simple,
Predisposición Genética a la Enfermedad,
Medición de Riesgo,
Frecuencia de los Genes,
Recurrencia Local de Neoplasia/epidemiología,
Factores de Transcripción Forkhead/genética,
Biomarcadores de Tumor/genética,
Chile/epidemiología,
Polimorfismo Genético,
Genotipo,
Reacción en Cadena de la Polimerasa
Giorgenon, Tatiana Marina Vieira;
Carrijo, Fabiane Tavares;
Arruda, Maurício Alamos;
Cerqueira, Taíse Lima Oliveira;
Barreto, Haiara Ramos;
Cabral, Juliana Brandão;
Silva, Thiago Magalhães da;
Magalhães, Patrícia Künzle Ribeiro;
Maciel, Léa Maria Zanini;
Ramos, Helton Estrela.
ABSTRACT Objectives: This observational study analyzed telomerase reverse transcriptase (pTERT) mutations in 45 fine-needle aspiration (FNA) specimens obtained from thyroid nodules followed by postoperatively confirmation of papillary thyroid cancer (PTC) diagnosis, examining their relationship with cli...
Factores de Edad,
Biopsia con Aguja Fina,
Análisis Mutacional de ADN,
Metástasis Linfática/diagnóstico,
Mutación/genética,
Estadificación de Neoplasias,
Valor Predictivo de las Pruebas,
Periodo Preoperatorio,
Pronóstico,
Regiones Promotoras Genéticas/genética,
Proteínas Proto-Oncogénicas B-raf/genética,
Telomerasa/genética,
Cáncer Papilar Tiroideo/diagnóstico,
Cáncer Papilar Tiroideo/genética,
Cáncer Papilar Tiroideo/patología,
Neoplasias de la Tiroides/diagnóstico,
Neoplasias de la Tiroides/genética,
Neoplasias de la Tiroides/patología,
Nódulo Tiroideo/diagnóstico,
Nódulo Tiroideo/genética,
Nódulo Tiroideo/patología
Pessôa-Pereira, Danielle;
Medeiros, Mateus Fernandes da Silva;
Lima, Virna Mendonça Sampaio;
Silva Jr, Joaquim Custódio da;
Cerqueira, Taíse Lima de Oliveira;
Silva, Igor Campos da;
Fonseca Jr, Luciano Espinheira;
Sampaio, Luiz José Lobão;
Lima, Cláudio Rogério Alves de;
Ramos, Helton Estrela.
ABSTRACT Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristi...
Factores de Edad,
Brasil/epidemiología,
Estudios Transversales,
Análisis Mutacional de ADN,
Enfermedad de Hashimoto/complicaciones,
Enfermedad de Hashimoto/genética,
Mutación/genética,
Prevalencia,
Pronóstico,
Proteínas Proto-Oncogénicas B-raf/genética,
Estudios Retrospectivos,
Cáncer Papilar Tiroideo/complicaciones,
Cáncer Papilar Tiroideo/epidemiología,
Cáncer Papilar Tiroideo/genética,
Neoplasias de la Tiroides/epidemiología,
Neoplasias de la Tiroides/genética
SUMMARY Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital ...
BACKGROUND: Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorl...
MicroARNs/genética,
ARN Largo no Codificante/genética,
Cáncer Papilar Tiroideo/patología,
Neoplasias de la Tiroides/patología,
Apoptosis,
Proliferación Celular,
Transformación Celular Neoplásica,
Progresión de la Enfermedad,
Regulación Neoplásica de la Expresión Génica,
Estadificación de Neoplasias,
Cáncer Papilar Tiroideo/genética,
Neoplasias de la Tiroides/genética,
Regulación hacia Arriba
