Results: 21

Isolation of flavonoids from Tagetes patula (French Marigold) flowers: Cytotoxic and oxidant activity in human cervical carcinoma cells

T agetes patula , known as French Marigold, belongs to the family Asteraceae. Human papillomavirus infection is considered one of the causes of cervical cancer. This study assessed the cytotoxic activity and intracellular oxidative capacity of compounds isolated from e...

Anticancer activity of Inula graveolens by induction of ROS-independent apoptosis and suppression of IL6-IL8 in cervical cancer cells

Cancer is an important disease that causing to deaths in the world. Cervical cancer is one of the most common among women and must be treated quickly to prevent cell proliferation. Natural products have been used for cancer treatment due to their antiproliferative and apoptosis induction pro...

Principais implicações terapêuticas à qualidade de vida de pacientes com câncer de colo uterino: uma revisão narrativa

Femina; 50 (6), 2022
O câncer de colo uterino é o quarto tipo mais incidente e fatal entre as mulheres no Brasil e no mundo, o que representa mundialmente em torno de 600 mil novos casos e mais de 300 mil mortes a cada ano. Assim como o diagnóstico, o tratamento da doença pode impactar de forma significativa a qualidade ...

Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications

Braz. j. med. biol. res; 54 (6), 2021
Epidermal growth factor receptor (EGFR) signaling and components of the fibrinolytic system, including urokinase-type plasminogen activator (uPA) and thrombomodulin (TM), have been implicated in tumor progression. In the present study, we employed cBioPortal platform (http://www.cbioportal.org/), cancer ...

Braquiterapia adaptativa guiada por resonancia magnética para el cáncer cervical localmente avanzado: experiencia del Hospital Carlos Van Buren

Introducción y objetivos: El tratamiento estándar para pacientes con cáncer cervical localmente avanzado (CCLA) se basa en radioterapia externa y quimioterapia concomitante seguida de braquiterapia adaptativa guiada por imágenes (BTAGI). El objetivo de este estudio fue describir los resultados del pr...

Standard treatment with bevacizumab as targeted therapy in cervical cancer

Rev. invest. clín; 72 (4), 2020
ABSTRACT Metastatic, recurrent, or persistent disease in cervical cancer has a poor prognosis. Historically, this group of patients has had limited treatment options, even with the best cytotoxic treatments (platinum-based chemotherapy [CT] doublets). Therefore, investigating new medications that help im...

Fatores prognósticos de resposta à quimioterapia em tumores avançados do colo uterino: o papel da neoangiogênese

Rev. Col. Bras. Cir; 46 (1), 2019
RESUMO Objetivo: analisar a expressão do Fator de Crescimento do Endotélio Vascular (VEGF), seu receptor (VEGFR-2), idade e tipo histológico de carcinomas avançados de colo uterino com relação à resposta clínica à quimioterapia neoadjuvante. Métodos: foram incluídas 40 pacientes com diagnós...

Oxidative stress: therapeutic approaches for cervical cancer treatment

Clinics; 73 (supl.1), 2018
OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human...

Antineoplastic potential of the aqueous crude extract of Eugenia uniflora L. in human cervical cancer

Abstract Considering the high prevalence of human cervical cancer and the adverse effects of the available treatments, it is important to develop studies involving plants. Eugenia uniflora L. is a Brazilian native plant widely used in folk medicine and some biological effects have already been described....

Manejo terapéutico y supervivencia del cáncer de cuello uterino en el Instituto Nacional de Oncología y Radiobiología (2004-2010)
Therapeutic management and survival of cervical cancer at the National Institute of Oncology and Radiobiology (2004-2010)

Introducción: el cáncer de cuello uterino es uno de los principales problemas de la salud pública en el mundo por sus altas tasas de incidencia y mortalidad en la mujer. Objetivos: describir el manejo de las pacientes diagnosticadas con cáncer cérvico uterino admitidas y atendidas en el Instituto Na...