SUMMARY: Angiogenesis, a process by which new blood vessels are generated from pre-existing ones, is significantly compromised in tumor development, given that due to the nutritional need of tumor cells, pro-angiogenic signals will be generated to promote this process and thus receive the oxygen and nutr...
ABSTRACT A 36-year-old black male presented with a progressive loss of visual acuity in both eyes for 7 years. He had a history of tractional retinal detachment in the right eye and vitreous hemorrhage followed by retinal detachment in the left eye. He denied any systemic illness, trauma, or drug abuse. ...
SUMMARY: This study is to investigate the role and mechanism of RGD peptide in laryngeal cancer stem cells (CSCs). Laryngeal cancer CD133+Hep-2 CSCs were sorted by flow cytometry. RGD peptide was co-cultured with sorted laryngeal CSCs. Cell proliferation was detected with CCK-8 assay. The mRNA levels of ...
Oligopéptidos/metabolismo,
Integrina alfaVbeta3/antagonistas & inhibidores,
Neoplasias Laríngeas,
Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores,
Proliferación Celular,
Western Blotting,
Citometría de Flujo,
Inmunohistoquímica,
Factor A de Crecimiento Endotelial Vascular/genética,
ARN Mensajero/antagonistas & inhibidores,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Células Madre Neoplásicas,
Neovascularización Patológica,
Cartilla de ADN
Introduction: Tissue factor (TF) expression has been described in various neoplasms and was correlated with angiogenesis and metastases. Objectives: To describe TF expression in colorectal cancers, correlating it with microvessel density and clinical and pathological variables. Methods: Immunohistochemis...
BACKGROUND: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for ...
Diabetes Mellitus/genética,
Diabetes Mellitus/metabolismo,
Diabetes Mellitus/patología,
Retinopatía Diabética/genética,
Retinopatía Diabética/metabolismo,
Retinopatía Diabética/patología,
Células Endoteliales,
Neovascularización Patológica/genética,
Retina/metabolismo,
Retina/patología,
Sirtuina 1/metabolismo
SUMMARY: Cancer known as a malignant tumor, is a class of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. The Ehrlich tumor is a mammary adenocarcinoma of mice developed in solid and ascitic forms. This study was aimed to investigate the effects ...
Carcinoma de Ehrlich/tratamiento farmacológico,
Paclitaxel/administración & dosificación,
Antineoplásicos Fitogénicos/administración & dosificación,
Paclitaxel/farmacología,
Antineoplásicos Fitogénicos/farmacología,
Netrina-1/antagonistas & inhibidores,
Factor VIII,
Apoptosis,
Inmunohistoquímica,
Ratones Endogámicos BALB C,
Neovascularización Patológica,
Densidad Microvascular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos
ABSTRACT The standard treatment for locally advanced cervical cancer (CC) is chemoradiotherapy. Once the bladder receives part of the radiation, a typical inflammatory condition that configures radiation-induced cystitis may develop. Chronic radiation-induced cystitis is commonly characterized by the bla...
ABSTRACT Background: Cancer gene therapy using a nonviral vector is expected to be repeatable, safe, and inexpensive, and to have long-term effectiveness. Gene therapy using the E3 and C1 (E3C1) domain of developmental endothelial locus-1 (Del1) has been shown to improve prognosis in a mouse transplante...
Secuencias de Aminoácidos,
Proteínas de Unión al Calcio/genética,
Proteínas de Unión al Calcio/uso terapéutico,
Carcinoma de Células Escamosas/irrigación sanguínea,
Carcinoma de Células Escamosas/terapia,
Moléculas de Adhesión Celular/genética,
Moléculas de Adhesión Celular/uso terapéutico,
Dominio Discoidina/genética,
Factor de Crecimiento Epidérmico/genética,
Factor de Crecimiento Epidérmico/uso terapéutico,
Terapia Genética,
Ratones Desnudos,
Trasplante de Neoplasias,
Neovascularización Patológica/terapia,
Células Tumorales Cultivadas
Vasculogenic mimicry (VM) plays an important role in human glioma progression and resistance to antiangiogenic therapy as a compensatory neovascularization mechanism in malignant tumors. Caveolin-1 (Cav-1) has been found to contribute to VM formation. However, it remains largely unknown whether Cav-1 exp...
Introducción. Las malformaciones arteriovenosas son lesiones relativamente raras e infrecuentes. Se caracterizan por presentar un aumento anormal en el número de vasos sanguíneos como consecuencia de un defecto en el desarrollo vascular. Constituyen un desafío diagnóstico y terapéutico para el méd...
