SUMMARY: Angiogenesis, a process by which new blood vessels are generated from pre-existing ones, is significantly compromised in tumor development, given that due to the nutritional need of tumor cells, pro-angiogenic signals will be generated to promote this process and thus receive the oxygen and nutr...
ABSTRACT Objective: To evaluate the effect of red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells. Methods: The study consisted of two experiments with four groups each (total: 57 hamsters). In the experiment 1, the ani...
Inhibidores de la Angiogénesis/uso terapéutico,
Antioxidantes,
Carcinoma 256 de Walker/irrigación sanguínea,
Mejilla,
Cricetinae,
Lisina/uso terapéutico,
Mesocricetus,
Modelos Animales,
Neoplasias de la Boca/irrigación sanguínea,
Neoplasias de la Boca/inducido químicamente,
Neoplasias de la Boca/tratamiento farmacológico,
Neovascularización Patológica/tratamiento farmacológico,
Própolis/uso terapéutico,
Resultado del Tratamiento,
Aumento de Peso
Abstract Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the an...
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and cells that infiltrate tumors. Pro-tumorigenic effec...
Quercetin shows protective effects against hepatopulmonary syndrome (HPS), as demonstrated in a rat model. However, whether these effects involve pulmonary vascular angiogenesis in HPS remains unclear. Therefore, this study aimed to assess the effect of quercetin on pulmonary vascular angiogenesis and ex...
Antioxidantes/farmacología,
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/análisis,
Western Blotting,
Conducto Colédoco/cirugía,
Modelos Animales de Enfermedad,
Síndrome Hepatopulmonar/tratamiento farmacológico,
Síndrome Hepatopulmonar/patología,
Inmunohistoquímica,
Ligadura,
Pulmón/irrigación sanguínea,
Pulmón/patología,
FN-kappa B/análisis,
Neovascularización Patológica/tratamiento farmacológico,
Neovascularización Patológica/patología,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Resultado del Tratamiento
BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to che...
Antiinflamatorios no Esteroideos/farmacología,
Apoptosis/efectos de los fármacos,
Neoplasias de la Mama/tratamiento farmacológico,
Resistencia a Antineoplásicos/efectos de los fármacos,
Neoplasias Pulmonares/secundario,
Neovascularización Patológica/tratamiento farmacológico,
Pirazoles/farmacología,
Sulfonamidas/farmacología,
Inhibidores de la Angiogénesis/farmacología,
Neoplasias de la Mama/patología,
Proliferación Celular/efectos de los fármacos,
Pirazoles/administración & dosificación,
Sulfonamidas/administración & dosificación,
Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores,
Celecoxib,
Línea Celular Tumoral,
Pollos,
Membrana Corioalantoides,
Ensayos de Selección de Medicamentos Antitumorales,
Etiquetado Corte-Fin in Situ
Of the numerous growth factors and cytokines that have been shown to have angiogenic effects, vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), appears to be a key factor in pathological situations which involve neovascularization as well as enhanced vascular pe...
Inhibidores de la Angiogénesis/farmacología,
Ensayos de Selección de Medicamentos Antitumorales,
Factores de Crecimiento Endotelial/antagonistas & inhibidores,
Endotelio Vascular/efectos de los fármacos,
Linfocinas/antagonistas & inhibidores,
Ratones Desnudos,
Neoplasias Experimentales/tratamiento farmacológico,
Neovascularización Patológica/tratamiento farmacológico,
Ftalazinas/farmacología,
Piridinas,
Proteínas Tirosina Quinasas Receptoras/antagonistas & inhibidores,
Receptores de Factores de Crecimiento/antagonistas & inhibidores,
Receptores de Factores de Crecimiento Endotelial Vascular,
Factor A de Crecimiento Endotelial Vascular,
Factores de Crecimiento Endotelial Vascular
