LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action

Zhao, Yanyin; Liu, Bingyou; Wang, Yi; Xiao, Baoguo.

Braz. j. med. biol. res; 53 (1), 2020

This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; i...

Interferón gamma/sangre, Interleucinas/sangre, Ratones Endogámicos C57BL, Neuritis Autoinmune Experimental/sangre, Neuritis Autoinmune Experimental/tratamiento farmacológico, ARN Mitocondrial, Reacción en Cadena en Tiempo Real de la Polimerasa, Nervio Ciático/efectos de los fármacos, Nervio Ciático/metabolismo, Linfocitos T Colaboradores-Inductores/efectos de los fármacos, Factores de Tiempo

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Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves

Nogueira, Maria Renata Sales; Amôr, Nádia Ghinelli; Michellin, Letícia Baccaro; Cury Filho, Milton; Rosa, Patrícia Sammarco; Latini, Ana Carla Pereira; Rodrigues, Luciana Silva; Lemes, Robertha Mariana Rodrigues; Lara, Flavio Alves; Pessolani, Maria Cristina Vidal.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND Although Mycobacterium leprae (ML) is well characterised as the causative agent of leprosy, the pathophysiological mechanisms underlying peripheral nerve damage still need further understanding. In vitro and in vivo studies have yielded insights into molecular mechanisms of ML interaction wit...

Ratones Desnudos, Mycobacterium leprae, Factores de Crecimiento Nervioso/metabolismo, Células de Schwann/metabolismo, Nervio Ciático/metabolismo

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Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes

Farias, V X; Uchoa, P N; Aquino, C P; Britto, L R G; Fonteles, M C; Leal-Cardoso, J H; Silva-Alves, K S; Havt, A; Prata, M M G; Heimark, D B; Nascimento, N R F; Santos, C F.

Braz. j. med. biol. res; 52 (6), 2019

The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8,...

Transporte Biológico Activo/fisiología, Western Blotting, Diabetes Mellitus Experimental/metabolismo, Ganglios Espinales/metabolismo, Inositol/metabolismo, ARN Mensajero/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Nervio Ciático/metabolismo, Estreptozocina, Regulación hacia Arriba

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Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury

Mao, P; Li, C R; Zhang, S Z; Zhang, Y; Liu, B T; Fan, B F.

Braz. j. med. biol. res; 51 (10), 2018

Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by hig...

Secuencia de Bases, Western Blotting, Mapeo Cromosómico, Modelos Animales de Enfermedad, Ganglios Espinales/lesiones, Ganglios Espinales/metabolismo, Ganglios Espinales/fisiopatología, Regulación de la Expresión Génica, Datos de Secuencia Molecular, Neuralgia/metabolismo, Traumatismos de los Nervios Periféricos/metabolismo, ARN Largo no Codificante/metabolismo, ARN Mensajero/genética, Nervio Ciático/metabolismo, Transcriptoma

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