Hypercapnia attenuates ventilator-induced lung injury through vagus nerve activation
Acta cir. bras; 34 (9), 2019
Abstract Purpose: To investigate the role of vagus nerve activation in the protective effects of hypercapnia in ventilator-induced lung injury (VILI) rats. Methods: Male Sprague-Dawley rats were randomized to either high-tidal volume or low-tidal volume ventilation (control) and monitored for 4h. The h...
Líquido del Lavado Bronquioalveolar/química, Citocinas/análisis, Modelos Animales de Enfermedad, Hipercapnia, Interleucina-8/análisis, Distribución Aleatoria, Ratas Sprague-Dawley, Factor de Necrosis Tumoral alfa/análisis, Vagotomía, Nervio Vago/cirugía, Lesión Pulmonar Inducida por Ventilación Mecánica/prevención & control