The relief of the impediment to urinary flow is the treatment of acute kidney failure due to urinary tract obstruction. However, there is a risk of inducing massive polyuria, which can be self-limited or produce severe contraction of the intravascular volume with pre-renal acute kidney failure and altera...
ABSTRACT Objetive Pelvicureteric junction (PUJ) obstruction is the main cause of hydronephrosis in childhood. Open pyeloplasty has been the gold standard treatment of this condition with success rate above 90%. The role of laparoscopic pyeloplasty (LP) in children is less well defined and has slowly em...
Rab7, an important member of the Rab family, is closely related to autophagy, endocytosis, apoptosis, and tumor suppression but few studies have described its association with renal fibrosis. In the early stage, our group studied the effects of Rab7 on production and degradation of extracellular matrix i...
Autofagia/fisiología,
Fibrosis,
Riñón/patología,
Enfermedades Renales/etiología,
Ratones Noqueados,
ARN/aislamiento & purificación,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal,
Regulación hacia Arriba,
Obstrucción Ureteral/complicaciones,
Proteínas de Unión al GTP rab/genética,
Proteínas de Unión al GTP rab/metabolismo
ABSTRACT Objective: It has been reported that phosphodiesterase-5 (PDE-5) inhibitors improve kidney function during acute and chronic renal failure. This study aimed to determine the possible therapeutic effects of tadalafil, a specific PDE-5 inhibitor, on renal fibrosis induced by unilateral ureteral o...
Polat, Emre Can;
Besiroglu, Huseyin;
Ozcan, Levent;
Otunctemur, Alper;
Eruyar, Ahmet Tugrul;
Somay, Adnan;
Ozbay, Nurver;
Cekmen, Mustafa;
Eraldemir, Ceyla;
Ozbek, Emin.
ABSTRACT Introduction: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Materials and Methods: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and ...
Cadherinas/sangre,
Modelos Animales de Enfermedad,
Fibrosis/tratamiento farmacológico,
Fibrosis/etiología,
Hidroxiprolina/sangre,
Inmunohistoquímica,
Enfermedades Renales/tratamiento farmacológico,
Enfermedades Renales/etiología,
Enfermedades Renales/patología,
Factor 2 Relacionado con NF-E2/uso terapéutico,
Óxido Nítrico/sangre,
Pirazinas/uso terapéutico,
Ratas Wistar,
Tionas,
Tiofenos,
Factor de Crecimiento Transformador beta1/sangre,
Obstrucción Ureteral/complicaciones,
Obstrucción Ureteral/tratamiento farmacológico,
Obstrucción Ureteral/patología
ABSTRACT Objective: The objective of the present study was to evaluate the effectiveness of HBO therapy on biochemical parameters, renal morphology and renal scintigraphy in rats undergoing chronic unilateral partial ureteral obstruction (UPUO). Material and methods: Thirty-five rats were divided into ...
Lesión Renal Aguda/sangre,
Lesión Renal Aguda/diagnóstico por imagen,
Lesión Renal Aguda/etiología,
Lesión Renal Aguda/prevención & control,
Biomarcadores/sangre,
Modelos Animales de Enfermedad,
Oxigenoterapia Hiperbárica,
Estrés Oxidativo,
Ratas Wistar,
Obstrucción Ureteral/sangre,
Obstrucción Ureteral/complicaciones,
Obstrucción Ureteral/terapia
ABSTRACT Objectives To investigate a possible causal relationship for stone formation in pelviureteric junction obstruction and to outline management options. Materials and Methods A literature search and evidence synthesis was conducted via electronic databases in the English language using the key ...
Hidronefrosis/complicaciones,
Hidronefrosis/congénito,
Hidronefrosis/metabolismo,
Hidronefrosis/cirugía,
Pelvis Renal/cirugía,
Laparoscopía/métodos,
Enfermedades Metabólicas/complicaciones,
Riñón Displástico Multiquístico/complicaciones,
Riñón Displástico Multiquístico/metabolismo,
Riñón Displástico Multiquístico/cirugía,
Nefrostomía Percutánea/métodos,
Factores de Riesgo,
Obstrucción Ureteral/complicaciones,
Obstrucción Ureteral/metabolismo,
Obstrucción Ureteral/cirugía,
Urolitiasis/complicaciones,
Urolitiasis/metabolismo,
Urolitiasis/cirugía
ABSTRACT Aim Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing betwe...
Arginina/análogos & derivados,
Arginina/sangre,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Hidronefrosis/etiología,
Hidronefrosis/metabolismo,
Hidronefrosis/patología,
Riñón/patología,
Nitratos/análisis,
Óxido Nítrico/análisis,
Óxido Nítrico/metabolismo,
Estrés Oxidativo/fisiología,
Adhesión en Parafina,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Valores de Referencia,
Superóxido Dismutasa/análisis,
Obstrucción Ureteral/complicaciones,
Obstrucción Ureteral/metabolismo
ABSTRACT Introduction and objective Indwelling double J ureteral stents are used routinely in the resolution of ureteral obstruction caused by different etiologies. Evaluation of urinary symptoms related to double-J stent, indicate that these affect 73-90% of patients. We conducted a prospective, rando...
Análisis de Varianza,
Quimioterapia Combinada,
Síntomas del Sistema Urinario Inferior/tratamiento farmacológico,
Síntomas del Sistema Urinario Inferior/etiología,
Síntomas del Sistema Urinario Inferior/prevención & control,
Ácidos Mandélicos/uso terapéutico,
Persona de Mediana Edad,
Estudios Prospectivos,
Calidad de Vida,
Reproducibilidad de los Resultados,
Método Simple Ciego,
Stents/efectos adversos,
Sulfonamidas/uso terapéutico,
Encuestas y Cuestionarios,
Factores de Tiempo,
Resultado del Tratamiento,
Uréter,
Obstrucción Ureteral/complicaciones,
Obstrucción Ureteral/terapia,
Obstrucción Ureteral,
Agentes Urológicos/uso terapéutico
