LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Li, Musheng; Zhao, Junhong; Cao, Meiwan; Liu, Ruitao; Chen, Guanhua; Li, Songyu; Xie, Yuanwen; Xie, Jing; Cheng, Yang; Huang, Ling; Su, Mingmin; Xu, Yuxin; Zheng, Mingyue; Zou, Kejian; Geng, Lanlan; Xu, Wanfu; Gong, Sitang.

Biol. Res; 53 (), 2020

BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...

Células Epiteliales/metabolismo, Mucosa Intestinal/metabolismo, Mastocitos/metabolismo, MicroARNs/metabolismo, Células CACO-2/citología, Claudinas/metabolismo, Exosomas/metabolismo, Enfermedades Inflamatorias del Intestino/metabolismo, Ocludina/metabolismo, Proteína de la Zonula Occludens-1/metabolismo, Células Cultivadas, Biología Computacional, Permeabilidad, Análisis de Matrices Tisulares

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Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1

Luo, Peng-Li; Wang, Yan-Jun; Yang, Yan-Yan; Yang, Jia-Jia.

Braz. j. med. biol. res; 51 (7), 2018

This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level of HIF-2α and tight junction proteins (occl...

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Hipoxia de la Célula/fisiología, Proliferación Celular, Células Endoteliales/química, Células Endoteliales/metabolismo, Glomérulos Renales/citología, Ocludina/metabolismo, Permeabilidad, Factores de Tiempo, Proteína de la Zonula Occludens-1/metabolismo

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Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa

Martinez, Carlos Augusto Real; Kadri, Caled Jaoudat; Kanno, Danilo Toshio; Alves Júnior, Antônio José Tibúrcio; Coy, Cláudio Saddy Rodrigues; Pereira, José Aires.

Acta cir. bras; 32 (1), 2017

Abstract Purpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and...

Claudina-3/análisis, Colon/química, Curcuma/química, Enema/métodos, Mucosa Intestinal/química, Ocludina/análisis, Aceites de Plantas/farmacología, Colon/efectos de los fármacos, Colon/patología, Colostomía, Heces, Inmunohistoquímica, Mucosa Intestinal/efectos de los fármacos, Mucosa Intestinal/patología, Ratas Wistar

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Citoquinas y patogénesis del edema macular diabético

Funatsu, Hideharu.

Salud(i)ciencia (Impresa); 12 (4), 2004

Diabetic macular edema (DME) is the leading cause of visual loss in diabetic patients and is characterized by accumulation of extracellular fluid in the retina. The most important mechanism involved is breakdown of the blood-retinal barrier (BRB), which is likely to be due to changes of tight junction pr...

Edema Macular, Diabetes Mellitus, Citocinas, Patogenesia Homeopática, Células Endoteliales, Fosforilación, Hiperglucemia, Isquemia, Ocludina, Volición, Uniones Intercelulares, Proteínas de la Zonula Occludens, Proteínas de Uniones Estrechas, Retinaldehído

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