LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Li, Musheng; Zhao, Junhong; Cao, Meiwan; Liu, Ruitao; Chen, Guanhua; Li, Songyu; Xie, Yuanwen; Xie, Jing; Cheng, Yang; Huang, Ling; Su, Mingmin; Xu, Yuxin; Zheng, Mingyue; Zou, Kejian; Geng, Lanlan; Xu, Wanfu; Gong, Sitang.

Biol. Res; 53 (), 2020

BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...

Células Epiteliales/metabolismo, Mucosa Intestinal/metabolismo, Mastocitos/metabolismo, MicroARNs/metabolismo, Células CACO-2/citología, Claudinas/metabolismo, Exosomas/metabolismo, Enfermedades Inflamatorias del Intestino/metabolismo, Ocludina/metabolismo, Proteína de la Zonula Occludens-1/metabolismo, Células Cultivadas, Biología Computacional, Permeabilidad, Análisis de Matrices Tisulares

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Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1

This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level of HIF-2α and tight junction proteins (occl...